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有机化学
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有机化学 ›› 2001, Vol. 21 ›› Issue (11): 993-996. 上一篇    下一篇

研究论文

反-Prelog还原体系、微水相羟氰化酶工作体系的发现 及光学活性化合物的合成

林国强;李祖义   

  1. 中国科学院上海有机化学研究所.上海(200032)
  • 发布日期:2001-11-25

Anti-prelog microbial reduction, (R)-oxynitrilase catalyzed cyanohydrination and the synthesis of optically active compounds

Lin Guoqiang;Li Zuyi   

  1. Shanghai Inst Organ Chem., CAS.Shanghai(200032)
  • Published:2001-11-25

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402

被引次数

1

我们从土壤中筛选出一株有自主知识产权的霉菌(白地霉G.38)，并发现它有独特的还原性能和优越的反应活性。与啤酒酵母作用相比，催化还原羰基，产物的立体化学上是按anti-Prelog的构型模式进行的。同时我们还开展了羟氰化酶合成光学活性的氰醇化合物的研究，发现和建立了一种适合粗酶作用的微水相工作体系，在工业上有实用前景。并筛选到3个高活性的(R)-氰醇酶源。

关键词: 微水相, 白地霉菌, 还原性, 羟氰化酶, 光学活性, 合成, 啤酒, 酵母

A new fungus (named Geotrichum sp. 38) was discovered from soil by screening. This microorganism possesses a unique reductive property and excellent reactivity. In contrast to Baker's yeast, it catalyzes the reduction of carbonyl group of various substrates according to an anti-Prelog mode. While carrying out the investigation of the synthesis of optically active cyanohydrins catalyzed by oxynitrilase, a new system called micro-aqueous reaction system suitable for use the of raw enzyme preparations was established with good prospects in industry. Three other (R)-oxynitrilase sources with high reactivity have also been obtained by screening.

Key words: GEOTRICHUM CANDIDUM, REDUCIBILTY, SYNTHESIS, BEER, YEAST

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