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有机化学
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有机化学 ›› 2001, Vol. 21 ›› Issue (3): 231-234. 上一篇    下一篇

研究论文

8,9-二氢-2H-吡喃并[5,6-g]喹啉-2-酮衍生物的合成

郑云红;夏奕;杨征宇;张倩;陈瑛;夏鹏   

  1. 复旦大学药学院有机化学教研室;原上海医科大学药学院;Natural Products Laboratory, School of Pharmacy, University;of North Carolina, Chapel Hill
  • 发布日期:2001-03-25

Synthesis of 8,9-dihydro-2H-pyrano-[5,6-g] quinolin-2- one derivatives

Zheng Yunhong;Xia Yi;Yang Zhengyu;Zhang Qian;Chen Ying;Xia Peng   

  • Published:2001-03-25

PDF

423

被引次数

20

报道了间氨基酚在PTS·H2O催化下，分别与不同结构的含α-位C－H的酮作用后，首先进行C环的环合，进而与乙酰乙酸乙酯反应，区域选择性地得到8,9-二氢-2H-吡喃并[5,6-g]喹啉-2-酮衍生物的新合成方法。

关键词: 喹啉P, 吡喃酮P, 杂环化合物, 三环烃P, 生物活性, 对甲苯磺酸, 氨基酚, 区域, 选择性, 合成法

A concise synthesis of 8,9-dihydro-2H-pyrano-[5,6-g]quinolin- 2-one derivatives was reported, using 3-amino-phenol as starting material. Treatment of 3-amino-phenol with ketones bearing αC-H at the presence of a catalyst PTS· H2O affords compound 2a～2d , followed by treatment with ethyl acetoacetate, gives target compound 3a～3d with regioselectivity.

Key words: QUINOLINE P, PYRANONE P, HETEROCYCLIC COMPOUNDS, TRICYCLIC HYDROCARBON P, BIOLOGICAL ACTIVITY, P- METHYLBENZENESULFONIC, AMINOPHENOL, REGION, SELECTIVITY, SYNTHESIS METHODS

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