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有机化学
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有机化学 ›› 2001, Vol. 21 ›› Issue (8): 599-602. 上一篇    下一篇

研究论文

微波辐射下4-芳基-7,7-二甲基-5-氧代-3,4,5,6,7,8-六氢 香豆素的合成及其晶 体结构

高原;屠树江;路再生;牛德仲;孙伯旺   

  1. 深圳大学师范学院化生系;徐州师范大学化学系.徐州(221009)
  • 发布日期:2001-08-25

Microwave-induced synthesis and crystal structure of 4-aryl-7,7- dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin

Gao Yuan;Tu Shujiang;Lu Zaisheng;Niu Dezhong;Sun Bowang   

  1. Xuzhou Teachers Coll, Dept Chem.Xuzhou(221009)
  • Published:2001-08-25

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304

被引次数

18 | 5

芳醛(1),5,5-二甲基-1,3-环已二酮(2)，麦氏酸(3)经微波辐射3～5min,不需任何催化剂，得到4-芳基-7,7-二甲基-5-氧代-3,4,5,6,7,8-六氢香豆素(4)。产物的结构经红外、核磁、元素分析及X-射线衍射法确证。对反应过程提出了可能的机理。

关键词: 微波辐射, 麦氏酸, 香豆素P, 合成法, 环已二酮, 芳香族醛, 晶体结构

A series of 4-aryl-7,7-dimethyl-5-oxo-3,4,5,6,7,8- hexahydrocoumarins (4) were synthesized by reaction of aryladehyde (1) and 5,5-dimethyl-1,3-cyclohexadione(2) with meldrum's acid (3) under microwave irradiation without ant catalysts. The structures were established on the basis of IR, 1^H NMR, elemental analysis and X-ray diffraction analysis. A possible mechanism for this reaction is positulated.

Key words: MICROWAVE RADIATION, COUMARIN P, SYNTHESIS METHODS, AROMATIC ALDEHYDE, CRYSTAL STRUCTURE

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