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有机化学
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有机化学 ›› 2003, Vol. 23 ›› Issue (11): 1277-1281. 上一篇    下一篇

研究论文

氨基酸衍生物PMV，PML和PMA的电喷雾质谱研究

李夏;梁燕;郑向军;梅毓华   

  1. 首都师范大学化学系;北京师范大学化学系;南京大学
  • 发布日期:2003-11-25

Electrospray Ionization Mass Spectra of Amino Acid Derivatives PMV, PML and PMA

Li Xia;Liang Yan;Zeng Xiangjun;Mei Yuhua   

  1. Department of Chemistry, Capital Normal University;Department of Chemistry, Beijing Normal University;State Key Laboratory of Coordination Chemistry, Nanjing University
  • Published:2003-11-25

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应用电喷雾（ESI）质谱及其多级串联质谱（MS~n）技术研究了三个氨基酸衍 生物N-(N-亚甲基-2-吡咯烷酮）-缬氨酸（PMV），N，N-二-（N-亚甲基-2-吡咯烷 酮）-亮氨酸（PML）和N，N-二-（N-亚甲基-2-吡咯烷酮）-β-丙氨酸（PMA）在电 喷雾条件下的质谱行为。在此条件下三个氨基酸衍生物PMV，PML和PMA可以质子化 形式PMVH~+，PMLH~+和PMAH~+存在，并且检测到它们的Na~+和K~+的加合物。在电 喷雾条件下PMV，PML和PMA优先采取C-N键的断裂，并且通过分子间的氢键作用形成 了许多二聚和三聚物种。

关键词: 质谱法, 氨基酸, 吡咯烷酮 P, 缬氨酸, 亮氨酸

The mass spectrometric behaviors of N-(2-oxopyn-olidin-l-ylmethyD- valine (PMV), N, N-bis(2-oxopyrrolidin-l-ylmethyl)-β-alanine (PMA) and N, N-bis(2-oxopyrrolidin-l-ylmethyl)-leucine (PML) were studied under electrospray ionization condition by multi-stage mass spectrometric (MS~n) experiments. Under this electrospray ionization condition, protonation forms of PMV, PML and PMA were observed, respectively, and their Na~+ and K~+ adducts were also detected. These three compounds followed the fragmentation passway with die preferential sequence relating to the cleavage of C-N bonds, and numerous dimmer and trimmer ions via hydrogen bonding interaction were formed under the experimental condition.

Key words: MASS SPECTROGRAPHY, AMINO ACID, PYRROLIDONE P, VALINE, LEUCINE

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