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有机化学
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有机化学 ›› 2003, Vol. 23 ›› Issue (12): 1411-1415. 上一篇    下一篇

研究论文

2,3-二取代-4-(IH-l,2,4-三唑-l-基)-5-苯基氢基噻吩的合成及生物活性研究

曹克广;王忠卫;赵信歧;方涛   

  1. 北京理工大学材料科学与工程学院;北京理工大学化工与环境学院
  • 发布日期:2003-12-25

Synthesis and Preliminary Biological Study of 2,3-Disubstituted-4- (IH-l, 2,4-triazo-l-yl) -5-phenylaminothiophene

Cao Keguang;Wang Zhongwei;Zhao Xinqi;Fang Tao   

  1. School of Material Science and Engineering,Beijing Institute of Technology;School of Chemical and Environmental Engineering,Beijing Institute of Technology
  • Published:2003-12-25

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合成了九个以噻吩为母体环的含三唑环的化合物——2，3-二取代-4-(1H-1， 2，4．三唑-1-基)-5-苯基氨基噻吩(2a-2i)，并测定了2a的晶体结构．晶体为三斜 晶系，P-1空间群，晶胞参数为：a=0．79816(15)nm，b=1．00259(13)nm，c=1． 4478(4)nm，a=100．326(16)°，β=94．69(2)°，r=106．083(9)°，V=1．0845 (4)nm～3，z=2，D_c=1．396 g／cm～3．初步生物活性表明所有目标化合物杀菌活 性较低，有一定的植物生长调节活性．

关键词: 三唑 P, 晶体结构, 生物活性, 噻吩 P, 植物生长调节剂, 杀菌剂

Nine novel compounds, 2,3-disubstuted-4-(l^-l,2,4-triazo-l-yl)-5- phenylaminothiophenes (2a~2i), were synthesized and identified by l H NMR, IR, MS spectra and elemental analysis. 3a was determined by X- ray single crystal diffraction analysis. Crystal structure of 2a belongs to triclinic system with space group P-l. The unit cell parameters are a =0.79816 (15) nm, b = 1.00259 (13) nm, c = 1.4478 (4) nm, a = 100.326 (16)°, /? = 94.69 (2)°, 7 = 106.083 (9)°, V= 1. 0845 (4) nm3, Z = 2, Dc = 1.396 g/cm3. Preliminary biological study showed that 2a ~ 2i exhibited relative plant growth regulativity but low fungicidal activities.

Key words: PYRRODIAZOLE P;CRYSTAL STRUCTURE;BIOLOGICAL ACTIVITY;THIOPHENE P, PLANT GROWTH REGULATORS;BACTERICIDAL AGENTS

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