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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (10): 1257-1259. 上一篇    下一篇

研究简报

聚乙二醇催化合成含三唑大环醚化合物

胡国强*,a, 许秋菊a, 张中泉a, 陈百泉a, 许启泰a, 黄文龙b, 张惠斌b, 黄胜堂b   

  1. a河南大学药学院 开封 475001;
    b中国药科大学新药中心 南京 210009
  • 收稿日期:2003-11-03 修回日期:2004-02-20 接受日期:2004-04-05 发布日期:2022-09-20
  • 基金资助:
    国家自然科学基金(No. 30070861)和河南大学科研基金(No. XK02043)资助项目.

Polyethylene Glycol Catalyzed Synthesis of New Macrocycle Ethers Containing Triazole Ring

HU Guo-Qiang*,a, XU Qiu-Jua, ZHANG Zhong-Quana, CHEN Bai-Quana, XU Qi-Taia, HUANG Wen-Longb, ZHANG Hui-Binb, HUANG Sheng-Tangb   

  1. aCollege of Pharmacy, Henan University, Kaifeng 475001;
    bCenter of Drug Discovery, China Pharmaceutical University, Nanjing 210009
  • Received:2003-11-03 Revised:2004-02-20 Accepted:2004-04-05 Published:2022-09-20
  • Contact: * E-mail: hgqxy@sina.com.cn

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香草醛(1)和3-取代-4-氨基-5-巯基-1,2,4-均三唑(4)分别与对二氯苄(2)缩合得相应的O,O'-取代二(香草醛)(3)和S,S'-取代双(氨基均三唑)(5). 3与5用聚乙二醇-600催化缩环合方便制得含三唑大环醚化合物6.

关键词: 三唑, 大环醚化合物, 合成

Condensation of vanillin (1) and 3-substituted-4-amino-5-mercapto-s-triazoles (4) with 1,4-di~(chloromethyl)benzene (2) gave the correspondingO,O'-di-substituted bis(aldehyde) (3) and S,S'-disubstituted-bis(s-triazole) (5), respectively. The titled macrocycles (6) were expediently prepared by condensation of3 with the appropriate 5 in the presence of polyethylene glycol 600.

Key words: triazole, macrocycle ether, synthesis