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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (11): 1407-1412. 上一篇    下一篇

研究论文

1-取代芳基-4-乙氧羰基-5-二甲氨基亚甲基氨基-1,2,3-三唑衍生物的新法合成

陈敏东*,a,b, 华维一*,b, 高桂枝a, 郑有飞a, 陈煦c, 杜建云c   

  1. a南京信息工程大学环境科学与工程系 南京 210044;
    b中国药科大学药学院 南京 210009;
    c天津师范大学化学系 天津 300074
  • 收稿日期:2003-11-17 修回日期:2004-02-23 接受日期:2004-05-11 发布日期:2022-09-21
  • 通讯作者: * E-mail: chenmdqqq@eyou.com
  • 基金资助:
    江苏省社会发展科技计划项目(No. BS2003034)、南京气象学院院基金(No. GD18)和天津市教委自然基金(No. 2001YY05)资助项目.

An Efficient Method for the Synthesis of Some New 1-Substituted Aryl-4-ethoxy- carbonyl-5-dimethylaminomethyleneamino-1,2,3-triazole and Their Derivatives

CHEN Min-Dong*,a,b, HUA Wei-Yi*,b, GAO Gui-Zhia, ZHENG You-Feia, CHEN Xuc, DU Jian-Yunc   

  1. aDepartment of Environmental Sciences & Engineering, Nanjing University of Information Science & Technology, Nanjing 210044;
    bCollege of Medicine, China Pharmaceutical University, Nanjing 210009;
    cDepartment of Chemistry, Tianjin Normal University, Tianjin 300074
  • Received:2003-11-17 Revised:2004-02-23 Accepted:2004-05-11 Published:2022-09-21

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以1-取代芳基-4-乙氧羰基-5-氨基-1,2,3-三唑衍生物为原料,用简单有效的方法在非常温和的条件下以较好的收率合成了一系列新型的1-取代芳基-4-乙氧羰基-5-二甲氨基亚甲基氨基-1,2,3-三唑及其衍生物,所得化合物未见文献报道.新化合物的结构用红外光谱、核磁共振、质谱和元素分析确证,同时初步研究了这些化合物的抑菌性能.

关键词: 1,2,3-三唑, 合成, 细菌

A simple and efficient method for the synthesis of some 1-substituted aryl-4-ethoxycarbonyl-5-disubstituted aminomethyleneamino-1,2,3-triazoles has been described. These compounds were first prepared from 1-substituted aryl-4-ethoxycarbonyl-5-amino-1,2,3-triazole and N,N-disubstituted formamides in the presence of phosphorus oxychloride under mild conditions in moderate to good yields. The structures werecharacterized by IR, 1H NMR, MS spectra and elemental analysis, and theirinhibiting effects on various bacteria were also screened.

Key words: 1,2,3-triazole, synthesis, bacteria