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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (11): 1461-1464. 上一篇    下一篇

研究简报

新型卤代羟基三苯醚的合成与抑菌活性研究

辛莹a, 王玉良*,a, 马梦林a, 陈淑华a, 陈洪超a, 杨志荣b, 廖薇b   

  1. a四川大学化学学院 成都 610064;
    b四川大学生命科学学院 成都 610064
  • 收稿日期:2004-01-31 修回日期:3004-04-13 接受日期:2004-06-01 发布日期:2022-09-21
  • 通讯作者: * E-mail: iamxinying@sohu.com
  • 基金资助:
    四川省科技厅(No. 02GY029037)资助项目.

Synthesis and Antimicrobial Activities of Halogenated Hydroxy Triphenyl Ethers

XIN Yinga, WANG Yu-Liang*,a, MA Men-Linga, CHEN Shu-Huaa, CHEN Hong-Chaoa, YANG Zhi-Rongb, LIAO Weib   

  1. aFaculty of Chemistry, Sichuan University, Chengdu 610064;
    bFaculty of Life Science, Sichuan University, Chengdu 610064
  • Received:2004-01-31 Revised:3004-04-13 Accepted:2004-06-01 Published:2022-09-21

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设计合成了对(间、邻)苯二酚二(4-氯-2-羟基苯基)醚(4a～4c)及对(间、邻)苯二酚二(4-氯-5-溴-2-羟基苯基)醚(5a～5c)共6个卤代羟基三苯醚类化合物,其结构均经1H NMR, IR, MS和元素分析证实,并且对其抑菌活性进行了初步测试.结果表明:此类化合物大多在低浓度下对大肠杆菌、金黄色葡萄球菌、白色念珠菌、白色葡萄球菌、变形杆菌、卡他双球菌、青枯假单胞菌等具有良好的抗菌活性.

关键词: 卤代羟基三苯醚, 抑菌活性, 合成

p (m, o)-Benzenediol di(4-chloro-2-hydroxyphenyl) ethers (4a～4c) and p (m, o)-benzenediol di(4-chloro-5-bromo-2-hydroxyphenyl) ethers (5a～5c) were synthesized, and their structures were characterized by 1H NMR, IR, MS spectra and elemental analysis. Their antimicrobial activitieswere investigated, and the preliminary results indicate that they have good antimicrobial activities on Escherichia coli (E. coli), Staphylococcus aureaus(S. aureus), Candida albicans (C. albicans), Staphylococcus albus (S. albus), Proteus vulgaris (P. vulgaris), Diplococcus catarrhalis (D. cata), Pseudomona ssolanacearum (P. solanacearum).

Key words: halogenated hydroxy triphenyl ether, antimicrobial activity, synthesis