有机化学 ›› 2004, Vol. 24 ›› Issue (11): 1458-1460. 上一篇    下一篇

研究简报

微波辐射下“一锅煮”法合成2-氨基-3-氰基-4-芳基-4H,5H-吡喃-[3,2-c]苯并吡喃-5-酮

蒋虹, 屠树江*, 房芳, 朱松磊, 李团结, 章晓镜, 史达清, 王香善   

  1. 徐州师范大学化学系 江苏省药用植物生物技术重点实验室 徐州 221009
  • 收稿日期:2004-03-11 修回日期:2004-04-29 接受日期:2004-05-28 发布日期:2022-09-21
  • 通讯作者: * E-mail: laotu2001@263.net
  • 基金资助:
    国家自然科学基金(No. 20372057)、江苏省自然科学基金(No. BK2001142)、江苏省有机合成重点实验室开放基金(No. JSK011)及江苏省教育厅自然科学基金(No. 01KJB150008)资助项目.

An Efficient One-Pot Synthesis of 2-Amino-3-cyano-4-aryl-4H,5H- pyrano[3,2-c]benzo[b]pyran-5-one under Microwave Irradiation

JIANG Hong, TU Shu-Jiang*, FANG Fang, ZHU Song-Lei, LI Tuan-Jie, ZHANG Xiao-Jing, SHI Da-Qing, WANG Xiang-Shan   

  1. Department of Chemistry, Xuzhou Normal University; Key laboratory of Biotechnology on Medical Plant of Jiangsu Proviance, Xuzhou 221009
  • Received:2004-03-11 Revised:2004-04-29 Accepted:2004-05-28 Published:2022-09-21

以芳醛、4-羟基香豆素、丙二腈为原料,乙醇为能量转移剂,哌啶为催化剂,在微波辐射下一步合成了一系列2-氨基-3-氰基-4-芳基-4H,5H-吡喃-[3,2-c]苯并吡喃-5-酮,反应在40~60 s时间内完成,产率60%~97%.

关键词: 芳醛, 4-羟基香豆素, 苯并吡喃, 微波

A series of 2-amino-3-cyano-4-aryl-4H,5H-pyrano[3,2-c]benzo[b]pyran-5-ones were synthesized by the reaction of 4-hydroxycoumarin,aromatic aldehydes and malononitrile using piperidine as catalyst, ethanol as energy transfer agent under microwave irradiation.

Key words: aromatic aldehyde, 4-hydroxylcoumarin, benzo[b]pyran, microwave