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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (12): 1610-1613. 上一篇    下一篇

研究简报

超声辐射合成5,7-二取代-2-(5-芳基-2-呋喃甲酰亚胺)-[1,2,4]-噻二唑并[2,3-a]嘧啶衍生物及其生物活性研究

薛思佳, 柯少勇*, 段李平, 李景智   

  1. 上海师范大学 生命与环境科学学院 上海 200234
  • 收稿日期:2004-01-05 修回日期:2004-06-15 接受日期:2004-06-15 发布日期:2022-09-20
  • 基金资助:
    江苏省“青蓝工程”科研基金(No. QL9801)、江苏省药用植物生物技术重点实验室基金(No. 02AXL13)、徐州师范大学研究生科研创新资助项目

Ultrasonically Irradiated Synthesis and Bioactivity of 5,7-Disubstituted-2-(5- aryl-2-furoylimino)-[1,2,4]-thiadiazolo[2,3-a]pyrimidine Derivatives

XUE Si-Jia, KE Shao-Yong*, DUAN Li-Ping, Li Jing-Zhi   

  1. College of Life and Environment Science, Shanghai Normal University, Shanghai 200234
  • Received:2004-01-05 Revised:2004-06-15 Accepted:2004-06-15 Published:2022-09-20
  • Contact: *E-mail: dqshi@263.net

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利用相转移催化法在超声辐射下合成了8种未见文献报道的5,7-二取代-2-(5-芳基-2-呋喃甲酰亚胺)-[1,2,4]-噻二唑并[2,3-a]嘧啶衍生物.其结构经元素分析、IR和1H NMR得到确证.该法具有操作简便,反应时间短等优点.初步的生物活性测试结果表明部分化合物具有一定除草活性.

关键词: 酰基硫脲, [1,2,4]-噻二唑并[2,3-a]嘧啶, 超声辐射, 相转移催化, 合成, 生物活性

Eight new 5,7-disubstituted-2-(5-aryl-2-furoylimino)-[1,2,4]-thiadiazolo[2,3-a]pyrimidine derivatives were synthesized under ultrasonic irradiation. All of them are new compoundsand their structures were exactly confirmed by IR, 1H NMR spectra and elemental analysis. Our method using the ultrasonic irradiation under the conditionof phase transfer catalyst (PTC) has the advantages of short reaction time andgood yield. The preliminary biological tests show that some of the target compounds have some inhibitory activities against weeds.

Key words: acyl thiourea, [1,2,4]-thiadiazolo[2,3-a]pyrimidine, ultrasonic irradiation, phase transfer catalysis, synthesis, bioactivity