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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (9): 1042-1044. 上一篇    下一篇

研究论文

水溶液中4-芳基-1,4-二氢吡啶衍生物的一步合成法

史达清*, 牟杰, 庄启亚, 王香善, 屠树江   

  1. 徐州师范大学化学系 江苏省药用植物生物技术重点实验室 徐州 221116
  • 收稿日期:2003-08-12 修回日期:2003-12-31 接受日期:2004-03-15 发布日期:2022-09-20
  • 基金资助:
    江苏省“青蓝工程”科研基金(No. QL9801)、江苏省药用植物生物技术重点实验室基金(No. 02AXL13)、徐州师范大学研究生科研创新(No. 03YJSK02)资助项目.

One-Pot Synthesis of 4-Aryl-1,4-dihydropyridines in Water

SHI Da-Qing*, MOU Jie, ZHUANG Qi-Ya, WANG Xiang-Shan, TU Shu-Jiang   

  1. Key Laborary of Biotechnology on Medical Plant of Jiangsu Province, Department of Chemistry, Xuzhou Normal University, Xuzhou 221116
  • Received:2003-08-12 Revised:2003-12-31 Accepted:2004-03-15 Published:2022-09-20
  • Contact: * E-mail: dqshi@263.net

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以芳醛、乙酰乙酸乙酯(或甲酯)、醋酸铵为原料在氯化三乙基苄基铵(TEBA)催化下在水中一步合成了4-芳基-1,4-二氢吡啶衍生物,该方法具有产率高、污染少、环境友好等特点.

关键词: 1,4-二氢吡啶, 水, 合成

A series of 4-aryl-1,4-dihydropyridines were synthesized by the reaction of aromatic aldehydes, ethyl (methyl) acetoacetate and ammonium acetate in the presence of triethylbenzylammonium chloride (TEBA) in water. Compared to the known report, this method has the advantages of good yields, less pollution and friendly environment.

Key words: 1,4-dihydropyridine, water, synthesis