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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (02): 176-181. 上一篇    下一篇

研究论文

2-取代芳基苯并[b]呋喃类化合物的合成

庞冀燕，汪波，陈之朋，许遵乐*   

  1. (中山大学化学与化学工程学院 广州 510275)
  • 收稿日期:2004-03-25 修回日期:2004-08-31 发布日期:2005-01-15
  • 通讯作者: 许遵乐

Synthesis of 2-Arylbenzo[b]furan Derivatives

PANG Ji-Yan,WANG Bo,CHEN Zhi-Peng,XU Zun-Le*   

  1. (Department of Applied Chemistry, School of Chemistry and Chemical Engineering,
    Sun Yat-Sen University, Guangzhou 510275)
  • Received:2004-03-25 Revised:2004-08-31 Published:2005-01-15
  • Contact: XU Zun-Le

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以4-取代苯乙炔化亚铜与3-甲氧基-4-羟基-5-溴肉桂酸甲酯为原料进行缩合反应得到2-取代芳基并[b]呋喃, 并将其衍生化, 得到14个2-芳基-5-烷基-7-甲氧基苯并[b]呋喃化合物, 并确证了其结构.

关键词: 苯乙炔化亚铜, 2-芳基苯并呋喃, 合成

2-Arylbenzo[b]furans were obtained via coupling reaction of the copper(I) arylacetylides with the phenylbromide, and then a series of derivatives were designed and synthesized by reduction, Vilsmeier, hydrolysis and substituted reaction. All the compounds were fully characterized by MS, 1H NMR, IR spectra and elemental analysis.

Key words: synthesis, 2-benzo[b]furans, copper(I) arylacetylides