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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (11): 1416-1419. 上一篇    下一篇

研究论文

用DCC/DMAP合成N-苄氧羰基氨基酸薄荷酯

李前荣*,1，顾承志1,2， 尹浩1，张毅1   

  1. (1中国科学院中国科技大学结构分析重点实验室 合肥 230026)
    (2石河子大学化学系 石河子 832003)
  • 收稿日期:2005-04-20 修回日期:2005-06-02 发布日期:2005-10-30
  • 通讯作者: 李前荣

Synthesis of Menthyl Esters of N-Benzoxycarbonylaminoacid Using DCC/DMAP

LI Qian-Rong*,1,GU Cheng-Zhi1,2,YIN Hao1,ZHANG Yi1   

  1. (1 Structure Research Laboratory, University of Science and Technology of China,
    Chinese Academy of Sciences, Hefei 230026)
    (2 Department of Chemistry, Shihezi University, Shihezi 832003)
  • Received:2005-04-20 Revised:2005-06-02 Published:2005-10-30
  • Contact: LI Qian-Rong

以乙腈为溶剂, 用DCC/DMAP偶合法合成了5个N-苄氧羰基氨基酸薄荷酯, 产率90%～94%. 起始原料氨基酸包括: 甘氨酸, DL-蛋氨酸, β-丙氨酸, L-缬氨酸和L-脯氨酸. 给出了目标产物的氢谱、碳谱、红外光谱、质谱、高分辨质谱和元素分析数据.

关键词: 氨基酸, 天然产物, 薄荷醇, DCC/DMAP, 酯化

Five menthyl esters of N-benzoxycarbonylaminoacid were synthesized in 90%～94% yields by using DCC/DMAP coupling method in acetonitrile. The starting material amino acids include glycine, DL-methionine, β-alanine, L-valine and L-proline. The data of 1H NMR, 13C NMR, IR, MS, HRMS spectra and elemental analysis of the target products were reported.

Key words: menthol, amino acid, esterification, natural product, DCC/DMAP