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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (12): 1598-1601. 上一篇    下一篇

研究简报

在三乙基苄基氯化铵相转移催化下水相中(E)-3-亚苄基-2,3-二氢吲哚-2-酮衍生物的合成

王香善*，曾兆森，李玉玲，史达清
屠树江，魏贤勇，宗志敏   

  1. (1徐州师范大学化学系 徐州221116)
    (2中国矿业大学化学工程学院 徐州221008)
    (3江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2005-02-21 修回日期:2005-06-20 发布日期:2005-11-30
  • 通讯作者: 王香善

Synthesis of E-Arylidene-2,3-dihydroindol-2-one Derivatives in Aqueous Media Catalyzed by Triethylbenzylammonium Chloride Phase-transfer Catalyst

WANG Xiang-Shan*, ZENG Zhao-Sen, LI Yu-Ling, SHI Da-Qing,
TU Shu-Jiang, WEI Xian-Yong, ZONG Zhi-Min   

  1. (1 Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)
    (2 School of Chemical Engineering, China University of Mining and Technol-ogy, Xuzhou 221008)
    (3 Key Laboratory of Biotechnology on Medical Plant of Ji-angsu Province, Xuzhou 221116)
  • Received:2005-02-21 Revised:2005-06-20 Published:2005-11-30
  • Contact: WANG Xiang-Shan

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以芳醛和2,3-二氢吲哚为原料, 以水为溶剂, 在室温以三乙基苄基氯化铵为催化剂合成了一系列的(E)-3-亚苄基-2,3-二氢吲哚-2-酮衍生物. 该方法具有反应条件温和、立体选择性好、产率高(72%～96%)和环境友好等优点. 产物的结构通过熔点, IR, 1H NMR和元素分析表征.

关键词: (E)-3-亚苄基-2,3-二氢吲哚-2-酮, 水, 合成, 三乙基苄基氯化铵

A series of E-arylidene-2,3-dihydroindol-2-one derivatives were synthesized from aromatic aldehyde and 2,3-dihydroindol-2-one at room temperature catalyzed by triethylbenzylammonium chloride (TEBAC) in water. This method has the advantages of mild reaction conditions, good stereoselectivity, high yields (72%～96%) and environmentally benign. The structures of the products were characterized by melting points, IR, 1H NMR spectra and elemental analysis.

Key words: E-arylidene-1,3-dihydroindol-2-one, water, synthesis, triethylbenzylammonium chloride