有机化学 ›› 2006, Vol. 26 ›› Issue (03): 391-395. 上一篇    

研究简报

5-(色酮-3-亚甲基)-3-芳基硫乙内酰脲的合成

惠永海1,曹玲华*,1,2   

  1. (1新疆大学化学化工学院 乌鲁木齐 830046)
    (2南开大学元素有机化学国家重点实验室 天津 300071)
  • 收稿日期:2005-04-12 修回日期:2005-09-22 发布日期:2006-02-28
  • 通讯作者: 曹玲华

Synthesis of 5-(Chromon-3-ylmethylidene)-3-arylthiohydantoin

HUI Yong-Hai1,CAO Ling-Hua*,1,2   

  1. .(1 College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046)
    (2 State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071)
  • Received:2005-04-12 Revised:2005-09-22 Published:2006-02-28
  • Contact: CAO Ling-Hua

α-氨基乙酸和芳基异硫氰酸酯为起始原料制备3-芳基-2-硫乙内酰脲, 然后在酸性条件下与3-甲酰基色酮发生类Knoevenagel缩合反应, 合成得到了16种新的5-(色酮-3-亚甲基)-3-芳基硫乙内酰脲类化合物. 所有化合物的结构均经IR, 1H NMR, LC-MS和元素分析确证, 并做了初步的生理活性测试

关键词: 硫乙内酰脲, 3-甲酰基色酮, 合成

Sixteen novel 5-chromon-3-ylthiohydantoins were synthesized by quasi-Knoevenagel condensation of 3-aryl-2-thiohydantoins, obtained from glycine and aryl isothiocyanetes, with 3-formylchromones in the presence of acid. Their structures were confirmed by IR, 1H NMR, LC-MS spectra and elemental analyses. Biological activity has been elementarily evaluated.

Key words: 3-formylchromone, synthesis, thiohydantoin