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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (04): 477-481. 上一篇    下一篇

综述与进展

芳醛-N-(1-苯基-1H-四唑-5-巯基)乙酰腙的微波合成及其晶体结构

魏太保，李满林，林奇，刘洪，张有明*   

  1. (西北师范大学化学化工学院 甘肃省高分子材料重点实验室 兰州 730070)
  • 收稿日期:2005-06-08 修回日期:2005-10-25 发布日期:2006-03-31

Microwave Assisted Synthesis and Crystal Structure of Arylal-dehyde- N-(1-phenyl-1H-tetrazole-5-yl)thiol Acetyl Hy-drazones

WEI Tai-Bao,LI Man-Lin,LIN Qi,LIU Hong,ZHANG You-Ming*   

  1. (Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering,
    Northwest Normal University, Lanzhou 730070)
  • Received:2005-06-08 Revised:2005-10-25 Published:2006-03-31

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在微波辐射下快速、高产率地合成了一系列含有四唑环的酰腙类化合物, 并对其进行了元素分析、红外以及核磁共振氢谱和碳谱表征. 对化合物4a的无色晶体进行了X射线晶体衍射. 结果表明, 该晶体属三斜晶系, 空间群P-1, V＝0.80070(38) nm3, Z＝2, Dc＝1.404 g•cm－3, a＝0.7382(1) nm, b＝0.9992(2) nm, c＝1.1535(2) nm, α＝81.41(2)°, β＝85.72(2)°, γ＝72.21(2)°, 分子结构呈反式构型, 通过分子间氢键组装成二聚体. 生物活性测试发现部分化合物具有抗菌活性.

关键词: 酰腙, 微波辐射, 生物活性, 四唑

A series of hydrazone compounds containing tetrazole ring were synthesized rapidly in high yields under the condition of microwave irradiation and confirmed by elemental analysis, IR, 1H NMR and 13C NMR spectra. The crystal structure of compound 4a was determined by X-ray diffraction method. It belongs to triclinic system with space group P-1, a＝0.7382(1) nm, b＝0.9992(2) nm, c＝1.1535(2) nm, α＝81.41(2)°, β＝85.72(2)°, γ＝72.21(2)°, Dc＝1.404 g•cm－3, V＝0.8007(38) nm－3, Z＝2. The crystal structure shows that the compound has trans configuration and characteristic dimers connected by intermolecular hydrogen bond. The bioassay result indicates that some of the compounds have relatively low antibacterial activity.

Key words: acylhydrazone, microwave irradiation, bioactivity, tetrazole