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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (06): 831-834. 上一篇    下一篇

研究论文

二[1-甲基-4-(1-甲基-4-硝基吡咯-2-酰胺基)吡咯-2-酰胺基乙基]胺的合成与表征

周成勇a,b，朱苗力1，杨频*,1   

  1. (1山西大学分子科学研究所化学生物学与分子工程教育部重点实验室 太原 030006)
    (2山西长治学院生化系 长治 046011)
  • 收稿日期:2005-09-13 修回日期:2005-12-23 发布日期:2006-05-31
  • 通讯作者: 杨频

Synthesis and Characterization of Bis{2-[1-methyl-4-(1-methyl-4-ni-tropyrrole-2-acylimido)pyrrole-2-acylimido]ethyl}amine

ZHOU Cheng-Yonga,b,ZHU Miao-Li1,YANG Pin*,1   

  1. (1 Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Educa-tion,
    Institute of Molecular Science, Shanxi University, Taiyuan 030006)
    (2 Department of Biochemistry, Changzhi College, Changzhi 046011)
  • Received:2005-09-13 Revised:2005-12-23 Published:2006-05-31
  • Contact: YANG Pin

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1403

被引次数

6

报道了一种对称平行的多酰胺分子——二[1-甲基-4-(1-甲基-4-硝基吡咯-2-酰胺基)吡咯-2-酰胺基乙基]胺的合成方法, 以期对DNA序列进行新的特异性识别和切割, 从而研制新型有效的工具酶或抗癌药物. 合成方法简便易行、耗时短、不需过柱分离, 每步合成都有较高产率.

关键词: 多酰胺, 二乙基三胺, DNA的识别与切割, 二[1-甲基-4-(1-甲基-4-硝基吡咯-2-酰胺基)吡咯-2-酰胺基乙基]胺, 吡咯

In this paper, the synthesis of a sort of symmetrical and parallel polyamide, bis{2-[1-methyl- 4-(1-methyl-4-nitropyrrole-2-acylimido)pyrrole-2-acylimido]ethyl}amine, was reported. The whole process was also simple and convenient without column chromatography with high yields. The target compound was anticipated to recognize DNA sequence specifically and cleave it at predetermined site.

Key words: polyamide, diethylenetriamine, pyrrole, recognition and cleavage of DNA, bis{2-[1-methyl-4-(1-methyl-4-nitropyrrole-2-acylimido)pyrrole-2-acylimido]ethyl}amine