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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (01): 116-119. 上一篇    下一篇

研究简报

N-取代乙醇胺对4-氟-1-酰基苯的选择性胺化反应

戴春亚，蔡良珍，赵韧，陶晓春*   

  1. (华东理工大学应用化学研究所 上海 200237)
  • 收稿日期:2006-04-26 修回日期:2006-05-20 发布日期:2006-12-30
  • 通讯作者: 陶晓春

Selective Amination of 4-Fluoro-1-acylbenzenes UsingN-Substituted Ethanolamine

DAI Chun-Ya,CAI Liang-Zhen,ZHAO Ren,TAO Xiao-Chun*   

  1. (Institute of Applied Chemistry, East China University of Science and Technology, Shanghai 200237)
  • Received:2006-04-26 Revised:2006-05-20 Published:2006-12-30
  • Contact: TAO Xiao-Chun

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研究了4-氟-1-酰基苯和N-取代乙醇胺在酰胺类溶剂或不加溶剂中反应, 在不需要金属催化剂和另外加碱的条件下选择性地得到胺化产物, 实验操作简单, 符合SNAr取代机理. 一系列羟乙基胺基酰基苯产物均经过元素分析(HRMS), IR, MS和NMR的测定.

关键词: 胺化反应, 4-氟-1-酰基苯, N-取代乙醇胺

A selective and simple amination of 4-fluoro-1-acylbenzenes was achieved by using N-substituted ethanolamine neatly or in amidated solvent. The procedure in the absence of metal catalysts and additional bases was carried out throughout SNAr substitution mechanism. A series of 4-[N-alkyl-N- (2-hydroxylethyl)]amino-1-acylbenzene products were characterized by elemental analysis (HRMS), IR, MS and NMR spectra.

Key words: amination, N-substituted ethanolamine, 4-fluoro-1-acylbenzene