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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (07): 898-901. 上一篇    下一篇

研究简报

联苯二甲酸类手性分子钳的微波合成

石云，赵志刚*，刘兴利   

  1. (西南民族大学化学与环境保护工程学院 成都 610041)
  • 收稿日期:2007-01-21 修回日期:1900-01-01 发布日期:2007-06-30
  • 通讯作者: 赵志刚*

Synthesis of Chiral Molecular Tweezers Based on O,O'-Diphenic Acid under Microwave Irradiation

SHI Yun,ZHAO Zhi-Gang*,LIU Xing-Li   

  1. (College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041)
  • Received:2007-01-21 Revised:1900-01-01 Published:2007-06-30
  • Contact: ZHAO Zhi-Gang*

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被引次数

5 | 4

在微波辐射条件下, 以联苯二甲酸为间隔基, L-氨基酸甲酯为手臂, 合成了7个新型手性分子钳. 其结构经1H NMR, IR, MS和元素分析所证实. 与常规加热的一般合成方法相比, 该法明显地提高了反应速度和产率. 初步的实验结果表明, 这类分子钳人工受体对D/L-氨基酸甲酯具有良好的对映选择性识别性能.

关键词: 联苯二甲酸, 手性分子钳, 分子识别, 微波辐射

Seven chiral molecular tweezers have been synthesized by using O,O'-diphenic acid as a spacer and L-amino acid methyl esters as arms under microwave irradiation. Their structures were confirmed by 1H NMR, IR, MS spectra and elemental analysis. Compared with the conventional heating method, this method considerably increased the reaction rate and yield. The preliminary results indicate that these chiral molecular tweezers have good enantioselective recognition for D/L- amino acid methyl esters.

Key words: molecular recognition, chiral molecular tweezer, microwave irradiation, O,O'-diphenic acid