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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (08): 985-988. 上一篇    下一篇

研究论文

含2-三氟甲基苯并咪唑的双噁二唑硫醚及其亚砜衍生物的合成

刘晨江，时天昊，李燕萍*   

  1. (新疆大学化学化工学院 石油天然气精细化工教育部重点实验室 乌鲁木齐 830046)
  • 收稿日期:2006-07-21 修回日期:1900-01-01 发布日期:2007-07-30
  • 通讯作者: 李燕萍*

Synthesis of Bisoxadiazolyl Substituted Sulfides and Sulfoxides Containing 2-Trifluoromethylbenzimidazol-1-yl Group

LIU Chen-Jiang, SHI Tian-Hao, LI Yan-Ping*   

  1. (Key Laboratory of Petroleum and Gas Fine Chemicals of Ministry of Education, College of Chemistry and
    Chemical Engineering, Xinjiang University, Ulumqi 830046)
  • Received:2006-07-21 Revised:1900-01-01 Published:2007-07-30
  • Contact: LI Yan-Ping*

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被引次数

2 | 1

芳甲酰肼和氯乙酸在二甲苯中反应生成了一系列的2-芳基-5-氯甲基-1,3,4-噁二唑(1a～1j), 继而与2-(2-三氟甲基苯并咪唑-1-亚甲基)-5-巯基-1,3,4-噁二唑(2)在乙醇-水的溶液中反应得到了一系列的含2-三氟甲基苯并咪唑的双噁二唑硫醚3a～3j, 再用硝酸氧化得到相应的亚砜衍生物4a～4j. 化合物的结构经元素分析, IR, 1H NMR确证.

关键词: 2-三氟甲基苯并咪唑, 合成, 1,3,4-噁二唑, 亚砜, 硫醚

A series of novel bisoxadiazolyl sulfides containing 2-trifluoromethylbenzimidazol-1-yl group 3a～3j and the corresponding sulfoxide derivatives 4a～4j were synthesized via condensation of 2-aryl-5-chloromethyl-1,3,4-oxadiazoles (1a～1j) with 2-(2-trifluoromethylbenzimidazol-1-ylmethyl)-5- mercapto-1,3,4-oxadiazoles (2) followed by oxi-dation with HNO3. The structures of these compounds were confirmed by elemental analysis, IR and 1H NMR spectra.

Key words: sulfoxide, 1,3,4-oxadiazole, synthesis, sulfide, 2-trifluoromethylbenzimidazole