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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (12): 1573-1576. 上一篇    下一篇

研究简报

微波辐射促进的3-烷基取代咪唑并[1,5-a]吡啶合成

王来宝a 潘佳a 汤灿林a 姜大炜a
邱飞a，步修仁b 王杰*,a   

  1. (a南京大学化学化工学院 南京 210093)
    (b Department of Chemistry, Clark Atlanta University, Atlanta, GA 30314, USA)
  • 收稿日期:2006-12-11 修回日期:2007-04-13 发布日期:2007-12-04
  • 通讯作者: 王杰

Synthesis of 3-Alkyl Substituted Imidazo[1,5-a]pyridines under Microwave Irradiation

WANG Lai-Baoa, PAN Jiaa, TANG Can-Lina, JIANG Da-Weia, QIU Feia
BU Xiu-Renb, WANG Jie*,a   

  1. (a College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093)
    (b Department of Chemistry, Clark Atlanta University, Atlanta, GA 30314, USA)
  • Received:2006-12-11 Revised:2007-04-13 Published:2007-12-04
  • Contact: WANG Jie

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分别在常规加热和微波辐射条件下, 由双(2-吡啶甲酰)、二(2-吡啶)甲酮与脂肪醛及醋酸铵在醋酸溶剂中反应成功地制备了3-烷基取代的咪唑并[1,5-a]吡啶. 实验结果表明: 微波法比传统的合成方法产率高、反应时间短. 产物的结构经过1H NMR, MS和元素分析表征.

关键词: 微波辐射, 咪唑并[1,5-a]吡啶, 合成

Under regular heating or microwave irradiation, 3-alkyl substituted imidazo[1,5-a]pyridines were synthesized from 2,2'-pyridil or di-2-pyridyl ketone and aliphatic aldehydes in the presence of ammonium acetate and acetic acid. Compared to the traditional heating condition, 3-alkyl imidazo[1,5-a]pyridines were obtained with higher yields and shorter reaction time under microwave irradiation. All products were characterized by their 1H NMR, MS spectra and elemental analysis.

Key words: imidazo[1,5-a]pyridine, synthesis, microwave irradiation