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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (03): 498-502. 上一篇    下一篇

研究简报

溴代二羟基硝基二苯醚类化合物的合成与抑菌活性研究

陈鸶a，辛莹b，詹妍c，侯若彤c，王玉良*,a
陈淑华a，杨志荣c   

  1. (a四川大学化学学院 成都 610064)
    (b成都医学院药学系 成都 610083)
    (c四川大学生命科学学院 成都 610064)
  • 收稿日期:2007-01-17 修回日期:2007-06-20 发布日期:2008-03-18
  • 通讯作者: 王玉良

ynthesis and Antimicrobial Activities of Brominated Dihy-droxyNitro Diphenyl Ethers

CHEN Sia,XIN Yingb,ZHAN Yanc,HOU Ruo-Tongc,WANG Yu-Liang*,a
CHEN Shu-Huaa, YANG Zhi-Rongc   

  1. (a College of Chemistry, Sichuan University, Chengdu 610064)
    (b Department of Pharmacy, Chengdu Medical College, Chengdu 610083)
    (c College of Life Science, Sichuan University, Chengdu 610064)
  • Received:2007-01-17 Revised:2007-06-20 Published:2008-03-18
  • Contact: WANG Yu-Liang

PDF

802

被引次数

12

综合考虑二苯醚类杀菌剂结构与活性关系的前期研究结果, 以双羟基二苯醚为原料, 经酸酐保护、硝化、去保护得到含硝基的双羟基二苯醚, 再经过溴代反应合成了7个新的溴代2,2'-, 2,4'-和4,4'-二羟基硝基二苯醚; 所有这些化合物的结构均经1H NMR, MS, IR和元素分析所证实; 并检测了合成的溴代二羟基硝基二苯醚化合物对两种有害菌的抑菌活性, 结果表明: 它们对所测试菌种具有优良的抑制效果, 其中3个化合物在质量分数为5×10－6的浓度下抑菌率超过100%, 能完全控制细菌的生长.

关键词: 溴代二羟基硝基二苯醚, 合成, 抑菌活性

Dihydroxy nitro diphenyl ethers were prepared by acylation, nitration and hydrolysis from dihydroxy diphenyl ethers, then brominated by Br2 to give seven new brominated dihydroxy nitro diphenyl ethers. The structures of the new compounds have been confirmed by 1H NMR, IR, MS spectra and elemental analysis. These compounds showed good antimicrobial activities against the tested bacteria.

Key words: synthesis, brominated dihydroxy nitro diphenyl ether, antimicrobial activity