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有机化学 ›› 2008, Vol. 28 ›› Issue (03): 494-497. 上一篇    下一篇

研究简报

4-(对取代苯基)-2-[2-(取代苯基)呋喃-4-甲酰胺]-1',3',4'-均三唑[1,2-d]-1,3,4-噻二唑类衍生物的合成和生物活性

薛思佳*，柴安，蔡志娟，卞王东   

  1. (上海师范大学生命与环境科学学院 上海 200234)
  • 收稿日期:2007-06-18 修回日期:2007-08-20 发布日期:2008-03-18
  • 通讯作者: 薛思佳

Synthesis and Biological Activity of 4-(p-Substituted phenyl)-2-[2-(substituted phenyl)-furoyl-4-amido]-1',3',4'-triazolo[1,2-d]-1,3,4-thiadiazoles

XUE Si-Jia*,CHAI An,CAI Zhi-Juan,BIAN Wang-Dong   

  1. (College of Life and Environment Science, Shanghai Normal University, Shanghai 200234)
  • Received:2007-06-18 Revised:2007-08-20 Published:2008-03-18
  • Contact: XUE Si-Jia

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以1-氨基-5-巯基-2-(对取代苯基)-1,3,4-均三唑和5-取代苯基-2-呋喃甲酰异硫氰酸酯为原料, 合成了10个未见文献报道的含苯环连呋喃的均三唑并噻二唑类衍生物, 通过元素分析, 1H NMR, IR和MS确定化合物的结构, 初步生物活性测试表明标题化合物具有一定的除草活性.

关键词: 酰胺, 1,3,4-均三唑并[1,2-d]-1,3,4-噻二唑, 合成, 除草活性

Ten unreported compounds 4-(p-substituted phenyl)-2-[2-(substituted phenyl)-furoyl-4-amido]- 1',3',4'-triazolo[1,2-d]-1,3,4-thiadiazoles were synthesized by the reaction of 1-amino-5-mercapto-2-(p- substituted phenyl)-1,3,4-triazoles with 5-(substituted phenyl)-2-furoyl isothiocyanates. Their structures were determined by elemental analysis, 1H NMR, IR and MS techniques, and preliminary bio-logical test indicated that the compounds had some herbicidal activities.

Key words: 1,3,4-triazolo[1,2-d]-1,3,4-thiadiazole, synthesis, amide, herbicidal activity