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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (05): 837-840. 上一篇    下一篇

研究论文

无溶剂、无催化剂条件下合成1,4,5,6,7,8-六氢喹啉-5-酮衍生物

荣良策*,a,b，韩红霞a，姜虹b，庄启亚a，姚昌盛a，屠树江a,b   

  1. (a徐州师范大学化学化工学院 徐州 221116)
    (b江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2007-06-20 修回日期:2007-08-24 发布日期:2008-05-20
  • 通讯作者: 荣良策

Synthesis of 1,4,5,6,7,8-Hexahydroquinolin-5-one Derivatives under Solvent-Free Conditions without Using Any Catalysts

RONG Liang-Ce*,a,b,HAN Hong-Xiaa,JIANG Hongb,ZHUANG Qi-Yaa
YAO Chang-Shenga,TU Shu-Jianga,b   

  1. (a College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116)
    (b Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou 221116)
  • Received:2007-06-20 Revised:2007-08-24 Published:2008-05-20
  • Contact: RONG Liang-Ce

PDF

976

被引次数

8

无溶剂、无催化剂条件, 在NH4OAc存在下以查尔酮和1,3-二酮为原料, 高产率地合成1,4,5,6,7,8-六氢喹啉-5-酮衍生物. 该方法具有反应条件温和、操作简单和环境友好等优点. 并通过IR, 1H NMR, 元素分析和X衍射确证产物的结构.

关键词: 1,3-环己二酮, 查尔酮, 1,4,5,6,7,8-六氢喹啉-5-酮, 无溶剂, 合成

Under solvent-free conditions, synthesis of 1,4,5,6,7,8-hexahydroquinolin-5-one derivatives from chalcones and 1,3-cyclohexanedione in the presence of NH4OAc was carried out in excellent yields without using any catalysts. This method has the advantages of mild reaction conditions, simple protocol, and friendly environment. The structures of the products were confirmed on the basis of IR, 1H NMR spectra, elemental analysis, and that of 3b was additionally confirmed by X-ray diffraction analysis.

Key words: chalcone, solvent-free, 1,4,5,6,7,8-hexahydroquinolin-4-one, synthesis, 1,3-cyclohexanedione