有机化学 ›› 2008, Vol. 28 ›› Issue (11): 1993-1996. 上一篇    下一篇

研究简报

含有苯基的青蒿素类似物的合成

吴锦明 ; 李 英*   

  1. (中国科学院上海药物研究所 上海 201203)
  • 收稿日期:2007-12-04 修回日期:2008-03-11 发布日期:2008-11-18
  • 通讯作者: 李 英

Synthesis of an Artemisinin Analog with Phenyl Group

WU, Jin-Ming; LI, Ying*   

  1. (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203)

  • Received:2007-12-04 Revised:2008-03-11 Published:2008-11-18
  • Contact: LI, Ying

为考察引入苯基的青蒿素类似物的抗疟活性, 我们设计了化合物7. 从苯甲醛出发, 经过10步反应, 制得光化学反应底物环烯醚16. 16经光氧化反应得到非期望产物17. 17的化学结构由X射线晶体衍射法测定.

关键词: 青蒿素类似物, 光氧化反应, X射线晶体衍射
,
合成

To inspect the antimalarial activity of artemisinin analog with a phenyl group (7), the phytooxygenation precursor 16 was synthesized from benzaldehyde via 10 reactions. However, the phytooxygenation product 17 was not the target compound 7. The structure of 17 was elucidated by X ray analysis.

Key words: artemisinin analog, phytooxygenation, X ray analys, synthesis