有机化学 ›› 2009, Vol. 29 ›› Issue (01): 55-60. 上一篇    下一篇

研究论文

聚乙二醇支持的2,5-二取代异噁唑啉衍生物的液相合成

何心伟; 金 杰; 王翠娥 ; 商永嘉*   

  1. (安徽师范大学化学与材料科学学院 安徽省分子固体重点实验室 芜湖 241000)
  • 收稿日期:2008-04-11 修回日期:2008-06-11 发布日期:2009-01-20
  • 通讯作者: 商永嘉*

Synthesis of 2,5-Disubstituted Isoxazolines Using Poly(ethylene glycol) as Soluble Polymer Support

He, Xinwei ; Jin, Jie ; Wang, Cuie; Shang, Yongjia*   

  1. (Anhui Key Laboratory of Functional Molecular Solids, College of Chemistry and Materials Science,
    Anhui Normal University, Wuhu 241000)
  • Received:2008-04-11 Revised:2008-06-11 Published:2009-01-20
  • Contact: Shang, Yongjia*

介绍了通过1,3-偶极环加成合成2,5-二取代异噁唑啉衍生物的液相合成方法, 利用聚乙二醇(PEG)支持的烯烃与由醛肟制得的腈氧化物反应制备了多种异噁唑啉衍生物, PEG解脱后产物的产率和纯度均很高.

关键词: 1,3-偶极环加成, 聚乙二醇, 异噁唑啉, 液相有机合成

An efficient liquid-phase synthesis of 2,5-disubstituted isoxazolines through a 1,3-dipolar cycloaddition is described. The poly(ethylene glycol) (PEG)-supported alkene reacted with nitrile oxides generated in situ from aldoximes, followed by cleavage from the PEG, to give isoxazolines in good yields and purities.

Key words: isoxazoline, liquid-phase organic synthesis, 1,3-dipolar cycloaddition., poly(ethylene glycol)