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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (11): 1804-1810. 上一篇    下一篇

研究论文

5-烷氧基-3,4-二卤-2(5H)-呋喃酮与α,ω-二胺的串联反应

宋秀美 汪朝阳* 李建晓 傅建花   

  1. (华南师范大学化学与环境学院 广州 510006)
  • 收稿日期:2009-01-21 修回日期:2009-04-25 发布日期:2009-06-22
  • 通讯作者: 汪朝阳 E-mail:wangwangzhaoyang@tom.com
  • 基金资助:

    国家级.国家自然科学基金

Tandem Reaction of 5-Alkoxy-3,4-dihalo-5H-furan-2-one with α,ω-Diamines

Song, Xiumei      Wang, Zhaoyang*          Li, Jianxiao          Fu, Jianhua   

  1. (School of Chemistry and Environment, South China Normal University, Guangzhou 510006)
  • Received:2009-01-21 Revised:2009-04-25 Published:2009-06-22
  • Contact: Zhaoyang Wang E-mail:wangwangzhaoyang@tom.com

PDF

1546

被引次数

35

在三乙胺作用下, 亲核试剂α,ω-二胺与5-烷氧基-3,4-二卤-2(5H)-呋喃酮在室温下发生串联的迈克尔加成-消除反应, 合成了16个新化合物. 通过旋光度, UV-Vis, IR, 1H NMR, 13C NMR, MS, 元素分析和X射线单晶衍射等表征方法, 确定了目标化合物的化学结构和绝对构型.

关键词: 5-烷氧基-3,4-二卤-2(5H)-呋喃酮, α,ω-二胺, 迈克尔加成, 串联反应

Four α,ω-diamines, serving as nucleophiles, were reacted with 5-alkoxy-3,4-dihalo-5H-furan- 2-one in the presence of triethylamine to give sixteen new compounds. The chemical structures and absolute configurations of the new compounds were confirmed via rotation, UV-Vis, IR, 1H NMR, 13C NMR, MS, elemental analysis and X-ray single crystal diffraction.

Key words: 5-alkoxy-3,4-dihalo-5H-furan-2-one, α,ω-diamine, Michael addition, tandem reaction