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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (01): 107-111. 上一篇    下一篇

研究简报

乳香大环二萜类化学成分研究

李福双，徐康平，袁寿洪，颜冬兰，刘让如，谭健兵，曾光尧，周应军，谭桂山*   

  1. (a中南大学药学院 长沙 410013) 
    (b中南大学湘雅医院药剂科 长沙 410008)
  • 收稿日期:2008-09-24 修回日期:2009-04-24 发布日期:2010-01-20
  • 通讯作者: 谭桂山 E-mail:tgs395@yahoo.com.cn
  • 基金资助:

    湖南省科技厅资助项目（编号：06sk3001）

Macrocyclic Diterpenes from Boswellia carterii Birdwood (Frankincense)

Li,Fushuang，Xu,Kangping，Yuan,Shouhong，Yan,Donglan，Liu,Rangru Tan,Jianbing，Zeng,Guangyao，Zhou,Yingjun，Tan,Guishan*   

  1. (a School of Pharmaceutical Sciences，Central South University，Changsha 410013) 
    (b Department of Pharmacy，Xiangya Hospital，Central South University，Changsha 410008)
  • Received:2008-09-24 Revised:2009-04-24 Published:2010-01-20

PDF

1217

被引次数

22

采用硅胶柱层析，制备薄层层析等色谱方法，从乳香CO2超临界提取物中分得7个大环二萜类化合物，经波谱方法鉴定为incensole acetate (1)，incensole (2)，incensole oxide acetate (3)，isoincensole acetate (4)，incensole oxide (5)，isoincensole oxide (6)，isoincensolol (7)，其中，化合物7为新化合物，化合物4为首次从该属植物中分离得到。采用四甲基偶氮唑蓝(MTT)法观察化合物对肿瘤细胞的抑制增殖作用。

关键词: 乳香, 化学成分, 大环二萜, 抗肿瘤, isoincensoleol

Seven macrocyclic diterpene compounds were isolated from Boswellia carterii Birdwood (Frankincense) and purified by silica-gel column chromatorgraphy and preparative thin-layer chromatography (TLC)。Their structures were elucidated as incensole acetate (1)，incensole (2)，incensole oxide acetate (3)，isoincensole acetate (4)，incensole oxide (5)，isoincensole oxide (6) and isoincensolol (7)。Compound 7 was a novel compound and compound 4 was isolated from this genus for the first time。Compounds 1～7 suppressing Bel-7402，Hela and SW-480 cells were investigated in vitro with cytotoxic activity.

Key words: Boswellia carterii Birdwood (Frankincense), chemical constituent, macrocyclic diterpene, anti-tumor, isoincensolol