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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (05): 740-744. 上一篇    下一篇

研究简报

温和条件下邻甲基苯磺酸铜催化三组分“一锅法”合成喹唑啉-4(3H)-酮衍生物

王敏*,1，张婷婷1，宋志国2   

  1. (1渤海大学化学化工学院 锦州 121000)
    (2渤海大学科技实验中心 锦州 121000)
  • 收稿日期:2009-09-08 修回日期:2009-11-25 发布日期:2009-12-17
  • 通讯作者: 王敏 E-mail:minwangszg@yahoo.com.cn

Three-Component One-Pot Synthesis of Quinazolin-4(3H)-one Derivatives Catalysed by Copper o-Toluenesulfonate under Mild Conditions

Wang Min*,1 Zhang Tingting 1 Song Zhiguo2   

  1. (1 College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121000)
    (2 Center for Science & Technology Experiment, Bohai University, Jinzhou 121000)
  • Received:2009-09-08 Revised:2009-11-25 Published:2009-12-17

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室温、无溶剂条件下, 邻甲基苯磺酸铜可有效催化邻氨基苯甲酸、胺和原甲酸酯三组分“一锅法”合成喹唑啉- 4(3H)-酮衍生物. 考察了原料配比及催化剂用量对产率的影响. 经催化剂循环研究, 催化活性无明显变化. 产物的结构通过熔点, IR, 1H NMR和元素分析进行测定和结构表征. 同时给出了可能的反应机理.

关键词: 邻甲基苯磺酸酮, 喹唑啉酮衍生物, 一锅法

Quinazolin-4(3H)-one derivatives were synthesized efficiently by a three components one-pot reaction of anthranilic acid, amines and ortho esters in the presence of copper o-toluenesulfonate at room temperature without solvent. The effects of molar ratio of raw materials and amount of catalysts on the yields were investigated. The result of catalyst circulation shows that there is no obvious change in its catalytic activity. The structures of products were characterized by melting points, IR, 1H NMR and elemental analysis. In addition, the probable mechanism for the reaction was proposed.

Key words: copper o-toluenesulfonate, quinazolinone derivative, one-pot synthesis