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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (05): 749-752. 上一篇    下一篇

研究简报

具有细胞毒性的两种四羟基甾醇化合物的分离与结构

廖小建，徐石海*，林慧   

  1. (暨南大学化学系 广州 510632 )
  • 收稿日期:2009-07-16 修回日期:2009-10-09 发布日期:2009-12-10
  • 通讯作者: 徐石海 E-mail:txush@jnu.edu.cn
  • 基金资助:

    国家级.863计划;国家自然科学基金

Isolation and Identification of Two Tetrahydroxylated Sterols with Cytotoxic Activity

LIAO Xiao-Jian, XU Shi-Hai, LIN Hui   

  1. (Department of Chemistry, Jinan University, Guangzhou 510632)
  • Received:2009-07-16 Revised:2009-10-09 Published:2009-12-10
  • Contact: XU Shi-Hai E-mail:txush@jnu.edu.cn

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被引次数

2 | 1

报道南海湛江硇洲岛软珊瑚Dendronephthya sp. 中两种具有细胞毒性的四羟基甾醇化合物: 23-降-24-亚甲基-麦角甾-3β,5α,6β,7β-四醇(1)和24-亚甲基-麦角甾-3β,6β,9α,19β-四醇(2), 其结构通过波谱和化学方法确定, 其中化合物1为新化合物, 化合物2首次从该属珊瑚中获得. 化合物1对肿瘤细胞BEL-7402, MCG, MCF, LOVO和HepG-2具有抑制作用, 其IC50值分别为32.2, 20.5, 2.0, 5.5和18.6 μg/mL; 化合物2对肿瘤细胞MCG和LOVO作用的IC50值分别为22.0和和13.8 μg/mL.

关键词: 软珊瑚, Dendronephthya sp., 多羟基甾醇, 细胞毒活性

Two cytotoxic activity sterols 23-nor-ergost-24(28)-ene-3β,5α,6β,7β-tetrol (1) and ergost-24(28)-ene-3β,6β,9α,19β-tetrol (2) from Dendronephthya sp. collected from Naozhou Islands of the South China Sea have been reported. Their structures were defined by spectroscopic and chemical methods. Sterol 1 is a new compound, which exhibited cytotoxicity against BEL-7402, MCG, MCF, LOVO and HepG-2 cells (IC50 32.2, 20.5, 2.0, 5.5 and 18.6 μg/mL, respectively). Sterol 2 also showed significant cytotoxicity against MCG and LOVO cells (IC50 22.0 and 13.8 μg/mL, respectively).

Key words: soft coral, Dendronephthya sp., sterol, cytotoxic activity