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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (07): 951-957. 上一篇    下一篇

综述与进展

结晶诱导不对称转化在拆分手性化合物中的研究进展

熊文说，王鸿，易喻，梅建凤，应国清*   

  1. (浙江工业大学药学院 杭州 310014)
  • 收稿日期:2009-08-31 修回日期:2010-10-20 发布日期:2009-12-30
  • 通讯作者: 应国清 E-mail:bioph@zjut.edu.cn
  • 基金资助:

    浙江省新世纪151人才基金资助(No.06-2-104)

Progress of Crystallization-Induced Asymmetric Transformation in Resolution of Chiral Compounds

XIONG Wen-Shuo, WANG Hong, YI Yu, MEI Jian-Feng, YING Guo-Qing   

  1. (College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014)
  • Received:2009-08-31 Revised:2010-10-20 Published:2009-12-30

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被引次数

14 | 1

结晶诱导动态拆分(CIDR)是对映异构体(或非对映异构体)的原位外消旋作用和选择性结晶过程的耦合. 结晶诱导不对称转化(CIAT)包括了CIDR过程, 也包括了结晶诱导分离具有单个或多个非对映异构体中心的异构体、顺反式烯烃的过程. 概述了CIAT和CIDR在拆分手性化合物中的研究进展.

关键词: 结晶诱导动态拆分, 结晶诱导不对称转化, 手性化合物, 拆分

Crystallization-induced dynamic resolution (CIDR) is a combination of racemization of enantiomers either as the free compounds or as diastereomeric salt with a chiral gegenion and selective crystallization. Crystallization-induced asymmetric transformation (CIAT) includes CIDR and other processes, which may include compounds with two or more diastereomeric centers and olefins. The progress of CIAT and CIDR in resolution of chiral compounds is summarized.

Key words: crystallization-induced dynamic resolution, crystallization-induced asymmetric transformation, chiral compound, resolution

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