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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (12): 1911-1913. 上一篇    下一篇

研究简报

cis-3-芳脲基-2-苯基-2-氧代萘并[1,2-d]-1,2-氧膦杂环戊烷合成

孔杜林，吴明书*，李倩倩，马静雅   

  1. (海南师范大学化学与化工学院 省部共建-热带药用植物化学教育部重点实验室 海口 571158)
  • 收稿日期:2010-03-12 修回日期:2010-06-25 发布日期:2010-07-02
  • 通讯作者: 孔杜林 E-mail:kongdulin2007@yahoo.com.cn

Stereospecific Synthesis of cis-3-Arylureido-2-phenyl-2-oxo- naphtho[1,2-d]-1,2-oxaphospholance

KONG Du-Lin, WU Ming-Shu, LI Qian-Qian, MA Jing-Ya   

  1. (Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158)
  • Received:2010-03-12 Revised:2010-06-25 Published:2010-07-02

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利用2-羟基-1-萘甲醛、芳基脲、苯基二氯化膦作为起始原料, 在无水甲苯中反应合成cis-3-芳脲基-2-苯基-2-氧代萘并[1,2-d]-1,2-氧膦杂环戊烷. 产物结构经IR, 1H NMR, 31P NMR和元素分析等进行了表征.

关键词: 串联反应, 有机膦杂环, 1,2-氧膦杂环戊烷

A general and efficient stereospecific synthesis of cis-3-arylureido-2-phenyl-2-oxo-naph-tho[1,2-d]-1,2-oxoaphospholance was studied utilizing 2-hydroxy-1-naphthaldehyde, arylurea and phenyl- dichlorophosphine as starting materials in anhydrous toluene. The product structures were characterized by IR, 1H NMR, 31P NMR spectral data and elemental analyses.

Key words: tandem reaction, organophosphorus heterocycle, 1,2-oxaphospholane