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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (9): 1292-1304. 上一篇    下一篇

综述与进展

炔基锌与醛的催化不对称加成反应研究进展

李高伟1，王晓娟2，赵文献*,1，郭保国1，郑昕1，王敏灿*,2   

  1. (1商丘师范学院化学系 有机新材料合成重点实验室 商丘 476000)
    (2郑州大学化学系 河南省化学生物与有机化学重点实验室 郑州 450052)
  • 收稿日期:2009-11-05 修回日期:2010-01-11 发布日期:2010-03-04
  • 通讯作者: 赵文献 E-mail:zhwx195812@yahoo.com.cn
  • 基金资助:

    国家级.国家自然科学基金

Progress on Catalytic Asymmetric Addition of Alkynylzinc Reagents to Aldehydes

Li Gaowei1 Wang Xiaojuan2 Zhao Wenxian*,1 Guo Baoguo1 Zheng Xin1 Wang Mincan*,2   

  1. (1 Key Laboratory of New Organic Materials Synthesis, Department of Chemistry, Shangqiu Normal University, Shangqiu 476000)
    (2 Henan Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou 450052)
  • Received:2009-11-05 Revised:2010-01-11 Published:2010-03-04

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被引次数

3 | 1

光学活性的炔丙醇是一类很重要的手性合成砌块, 而末端炔对醛的不对称亲核加成是合成手性二级炔丙醇非常有效的方法. 以手性配体的结构类型为依据, 综述了炔基锌试剂对醛的不对称加成反应的研究进展.

关键词: 不对称合成, 醛, 炔丙醇, 炔基化

Optically active propargylic alcohols are important and versatile building blocks in asymmetric synthesis. The direct enantioselective addition of terminal alkynes to aldehydes is a very effective way in the synthesis of chiral secondary propargylic alcohols and has gained considerable significance. Research developments in the asymmetric addition of zinc alkynylides to aldehydes are reviewed according to different structure types of chiral ligands.

Key words: asymmetric synthesis, aldehyde, propargylic alcohol, alkynylation