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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (01): 136-140. 上一篇    下一篇

研究简报

N-(香豆素-3-甲酰基)-N -取代硫脲衍生物的合成及生物活性

刘志昌*，刘晓霞，王应红，杨录   

  1. (乐山师范学院化生学院 乐山 614000)
  • 收稿日期:2010-05-19 修回日期:2010-07-29 发布日期:2010-08-19
  • 通讯作者: 王应红 E-mail:wyhpg@126.com
  • 基金资助:

    姜黄的开发及综合利用

Synthesis and Biological Activities of N-Coumarin-3-formacyl-N - substitute Thioreas De-rivatives

LIU Zhi-Chang, LIU Xiao-Xia, WANG Ying-Hong, YANG Lu   

  1. (Department of Chemistry and Life Sciences, Leshan Teacher s College, Leshan 614000)
  • Received:2010-05-19 Revised:2010-07-29 Published:2010-08-19
  • Contact: WANG-ying hong yinghong E-mail:wyhpg@126.com

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以香豆素-3-甲酸与亚硫酰氯的反应产物香豆素-3-甲酰氯, 与硫氰酸钾反应, 再与各种杂环胺反应合成了N-(香豆素-3-甲酰基)-N -取代硫脲类衍生物. 其结构由IR, 1H NMR, 质谱和元素分析所表征, 并初步研究了目标化合物抗菌活性和植物生长促进作用, 发现它们大多数有优良的抑菌活性和较明显的植物生长促进活性.

关键词: 香豆素, 硫脲衍生物, 合成, 生物活性, 抑菌活性, 生长素活性

The N-coumarin-3-formacyl-N -substitute thiorea derivatives 4a～4f were synthesized by the reactions of different arylamine with coumarin-3-carbonyl isothiocynates which were prepared from coumarin-3-formacyl chloride and potassium thiocyanate. The structures of compounds 4a～4f were characterized by IR, 1H NMR, MS techniques and elementary analysis, and biological activities were also originally studied. The results of biological activities showed that some compounds 4a～4f have potent antibacterial activities and quite evident auxin activities.

Key words: coumarin, thiourea derivative, synthesis, biological activity, antibacterial activity, auxin activity

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