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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (07): 1064-1068. 上一篇    下一篇

研究论文

无溶剂合成1,3,5-三芳基-2-芳酰基环己醇衍生物和晶体结构

刁晓菊1，季红楼2，殷姗2，荣良策*,2，屠树江2   

  1. (1徐州医学院 徐州 221004)
    (2徐州师范大学化学化工学院 徐州 221116)
  • 收稿日期:2010-10-27 修回日期:2011-02-04 发布日期:2011-03-04
  • 通讯作者: 荣良策 E-mail:lcrong@xznu.edu.cn

Synthesis of 1,3,5-Triaryl-2-aroylcyclohexanol Derivatives and Crys-tal Structure under Solvent-Free Conditions

Diao Xiaoju1 Ji Honglou2 Yin Shan2 Rong Liangce*,2 Tu Shujiang2   

  1. (1 Xuzhou Medical College, Xuzhou 221004)
    (2 College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116)
  • Received:2010-10-27 Revised:2011-02-04 Published:2011-03-04
  • Contact: Rong LiangCe E-mail:lcrong@xznu.edu.cn

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被引次数

2

在NaOH存在下室温研磨查尔酮与丙二腈, 可以有效地得到1,3,5-三芳基-2-芳酰基环己醇衍生物, 本合成方法反应时间短、操作简单、产率高, 符合绿色化学特点. 产物结构经过红外、核磁、元素分析和高分辨质谱确证, 并对3b做了单晶衍射测定.

关键词: 查尔酮, 丙二腈, 无溶剂, 研磨, 环境友好

An efficient synthesis of 1,3,5-triaryl-2-aroylcyclohexanol derivatives from chalcone and malononitrile was reported in the presence of sodium hydroxide under solvent-free conditions at room temperature. The advantages of this procedure were simple protocol, high yields and environment friendliness. Their structures were determined by IR, 1H NMR spectra, elemental analysis and HRMS spectra, and 3b was additionally confirmed by X-ray diffraction analysis.

Key words: chalcone, malononitrile, solvent-free, grinding, environment friendliness