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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (10): 1613-1617. 上一篇    下一篇

研究论文

微波促进的非环核苷类化合物的合成

牛红英1,2，袁腾飞1，渠桂荣*,1，李德阳1，毛润泽1，金鑫1，杨西宁1，郭海明*,1   

  1. (1河南师范大学化学与环境科学学院 绿色化学介质与反应教育部重点实验室 新乡 453007)
    (2河南科技学院化学化工学院 新乡 453003)
  • 收稿日期:2011-02-16 修回日期:2011-04-15 发布日期:2011-05-09
  • 通讯作者: 郭海明 E-mail:ghm@htu.cn

Microwave Promoted Synthesis of Acyclic Purine Nucleosides

Niu Hongying1,2 Yuan Tengfei1 Qu Guirong*,1 Li Deyang1 Mao Runze1 Jin Xin1 Yang Xining1 Guo Haiming*,1   

  1. (1 Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007)
    (2 School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003)
  • Received:2011-02-16 Revised:2011-04-15 Published:2011-05-09
  • Contact: Hai-Ming GUO E-mail:ghm@htu.cn

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被引次数

6 | 2

以嘌呤碱基和各种α,β-不饱和醛为原料, 用三乙胺作为催化剂, 在微波的促进下, 通过Michael加成反应和原位还原, 高效地合成了一系列非环核苷类新化合物. 得到的目标化合物通过核磁共振图谱、高分辨质谱进行了确认.

关键词: 非环核苷, α,β-不饱和醛, Michael加成, 微波, 三乙胺

Acyclic purine nucleosides were synthesized in good to high yields via Michael addition reaction of purine bases and α,β-unsaturated aldehydes under microwave irradiation and reduced by NaBH4 in situ. The structures of all compounds are characterized by NMR and HRMS techniques.

Key words: acyclic nucleoside, α,β-unsaturated aldehyde, Michael addition reaction, microwave, triethyl-amine