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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (9): 1279-1283. 上一篇    下一篇

研究简报

S-2-甲氧基环己酮的合成研究

毛海舫，潘仙华*，郎希红   

  1. (上海应用技术学院 生物与食品工程系 上海 200235)
  • 收稿日期:2005-10-26 修回日期:2005-12-28 发布日期:2006-09-11
  • 通讯作者: 潘仙华

Synthetic Study on S-2-Methoxycyclohexanone

MAO Hai-Fang,PAN Xian-Hua*,LANG Xi-Hong   

  1. (School of Biotechnology and Food Processing Engineering, Shanghai Institute of Technology, Shanghai 200235)
  • Received:2005-10-26 Revised:2005-12-28 Published:2006-09-11
  • Contact: PAN Xian-Hua

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优化了S-2-甲氧基环己酮的合成方法, 该合成路线产率高、成本低、适合于生产; 并利用S-2-甲氧基环己酮合成了用于制备新一类β-内酰胺类抗生素sanfetrinem cilexetil 的关键中间体2.

关键词: sanfetrinem cilexetil, β-内酰胺类抗生素, 不对称合成, S-2-甲氧基环己酮

The synthetic method for the production of S-2-methoxycyclohexanone has been improved. The synthetic process, featured with high yield and low cost, can be applicable to the industrial production. The key intermediate 2, used for the preparation of the new classical β-lactam of sanfetrinem cilexetil, was obtained from the S-2-methoxycyclohexanone.

Key words: sanfetrinem cilexetil, β-lactam, asymmetric synthesis, S-2-methoxycyclohexanone