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有机化学
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有机化学 ›› 2001, Vol. 21 ›› Issue (12): 1126-1131. 上一篇    下一篇

研究论文

1-(2'-苯基-1', 2', 3'-三唑-4'-甲酰基)-4-芳基氨基硫脲及其 环化产物的合 成

刘方明;王宝雷;张正方   

  1. 新疆大学化学系.新疆(830046)
  • 发布日期:2001-12-25

Studies on 1-(2'-phenyl-1', 2', 3'-triazol-4'-formyl)-4- arylthiosemicarbazides and related heterocyclic compounds

Liu Fangming;Wang Baolei;Zhang Zhengfang   

  1. Xinjiang Univ, Dept Chem.Xinjiang(830046)
  • Published:2001-12-25

PDF

701

被引次数

38

以2-苯基-1,2,3-三唑-4-甲酰肼为原料合成了几种新的1-(2'-苯基-1',2',3'-三唑-4'-甲酰基)-4-芳基氨基硫脲，在不同条件下环化，制得一系列新的1,3,4-噻二唑、1,3,4-恶二唑和1,2,4-均三唑衍生物。化合物的结构经元素分析、IR、^1HNMR和MS确证，并对其波谱性质进行了讨论。

关键词: 氨基硫脲P, 氮杂环化合物, 三唑酮, 波谱分析, 硫酮, 三唑P, 噻二唑P, 恶二唑, 环化, 曼尼希碱, 合成

A series of new acyl thiosemicarbazide derivatives (2) were synthesized by addition reaction of 2-phenyl-1, 2, 3- triazol-4- formyl hydrazide (1) with several aryl isothiocyanates, which cyclized under different conditions to give 1, 3, 4-thiadiazole, 1, 3, 4- oxadiazole or 1, 2, 4-triazol- 5-thione derivatives (3, 4 or 5～7). The Mannich bases of 1, 2, 4-triazol-5-thione derivatives (5～7) were also synthesized.

Key words: THIOSEMICARBAZIDE P, NITROGEN HETEROCYCLICS, TRIADIMEFON, SPECTROMETRIC ANALYSIS, THIOKETONE, PYRRODIAZOLE P, THIADIAZOLE P, FURODIAZOLE (=OXDIAZOLE), CYCLIZATION, MANNICH BASE, SYNTHESIS

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