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有机化学
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有机化学 ›› 2001, Vol. 21 ›› Issue (12): 1137-1141. 上一篇    下一篇

研究论文

N-取代-N'-(2', 3', 4', 6'-四-O-乙酰基-β-D-吡喃葡萄糖基) (酰)氨基硫脲 的合成

李明;文丽荣;景淑霞;张玉冰;杨华铮;张书圣   

  1. 南开大学元素有机化学研究所.天津(300071);青岛化工学院应用化学系.青岛 (266042);兰州大学应用有机化学国家重点实验室.兰州(730000)
  • 发布日期:2001-12-25

N-substituted-N'-(2', 3', 4', 6'-tetra-O-acetyl)-β- D- glucopyranosyl thiocarbamides and thiosemicarbazides

Li Ming;Wen Lirong;Jing Shuxia;Zhang Yubing;Yang Huazheng;Zhang Shusheng   

  1. Nankai Univ, Elementoorgan Chem Lab.Tianjin(300071);Qindao Inst Chem Technol, Dept Appl Chem.Qingdao(266042);Lanzhou Univ, State Key Lab Appl Organ Chem.Lanzhou(730000)
  • Published:2001-12-25

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681

被引次数

5

利用2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖异硫氰酸酯(Ⅰ)分别和芳酰肼(Ⅱ)，2-氨基-5-烷基/芳基-1,3,4-噻二唑(Ⅲ),3-烷基/芳基-4-氨基-5-巯基-1,2,4-三唑(Ⅳ)，O,O-二烷基(硫代)磷酰肼(Ⅴ,Ⅵ)反应，制得了目标物1a～1c,2d～2e,3f～3i,4j～4k和5l等12种新化合物，IR，^1HNMR和MS分析结果证明产物为β构型。

关键词: 异硫氰酸酯, 糖基, 氨基硫脲, 波谱分析, 硫脲类, 合成

The reaction of 2, 3, 4, 6-tetra-O-acetyl-β-D- glucopyranosyl isothiocynate (Ⅰ) with aroyl hydrazine(Ⅱ), 2-amino-5-alkyl/aryl-1, 3, 4-thiadiazoles (Ⅲ), 3-alkyl/aryl-4- amino-5-mercapto-1, 2, 4- triazoles (Ⅳ) or O, O-dialkyl (thio) phosphorohydrazidates (Ⅴ, Ⅵ) furnished twelve new products, which structures were assigned as 1a～ 1c, 2d～2e, 3f～3i, 4j～4k and 5l respectively (all with β- configuration) on the basis of EA and spectral data.

Key words: ISOTHIOCYANATE, THIOSEMICARBAZIDE, SPECTROMETRIC ANALYSIS, SULFOCARBAMIDES, SYNTHESIS

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