有机化学 ›› 2003, Vol. 23 ›› Issue (4): 387-389. 上一篇    下一篇

研究论文

手性氨基酚催化二乙基锌对芳香醛的不对称加成反应

李新生;沈宗旋;葛健锋;张雅文   

  1. 苏州大学化学化工系
  • 发布日期:2003-04-25

Enantioselective Addition of Diethylzinc to Aromatic Aldehydes with Aminohenol as Catalysts

Li XinSheng;Shen ZongXuan;Ge JianFeng;Zhang YaWen   

  1. Department of Chemistry and Chemical Engineeing,Suzhou University
  • Published:2003-04-25

用易得的原料合成了4个手性氨基酚,这些化合物成功地催化了二乙基锌对醛 的不对称加成反应.其中1a催化间氯苯甲醛和二乙基锌的加成反应获得了较高的化 学产率(95%)和较好的ee值(57%).

关键词: 氨基酚, 锌化合物, 芳香族醛, 不对称合成, 加成反应, 催化反应

Four aminophenols have been prepared and evaluated as the catalysts for the enantioselective addition of diethylzinc to aromatic aldehydes. ligand la was found to show the best asymmetric induction in the catalysis of the reaction of m-chlorobenzaldehyde to provide sec- alcohol with high yield (95%) and moderate ee (57%).

Key words: AMINOPHENOL;ZINC COMPOUNDS;aromatic aldehyde;ASYMMETRICAL SYNTHESIS, ADDITION REACTION;CATALYTIC REACTION

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