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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (06): 786-789. 上一篇    下一篇

研究简报

KF-Al2O3催化下二-γ-吡喃并[2,3-a;2',3'-f]萘衍生物的合成

周杰兴a,b，王香善*,a,c，曾兆森a
张梅梅a，史达清a,c，屠树江a,c   

  1. (a徐州师范大学化学系 徐州 221116)
    (b淮海工学院化学工程系 连云港 222005)
    (c江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2006-08-22 修回日期:1900-01-01 发布日期:2007-05-21
  • 通讯作者: 王香善

Synthesis of Di-γ-pyrano[2,3-a;2',3'-f]naphthalene Derivatives Catalyzed by KF/Al2O3

ZHOU Jie-Xinga,b, WANG Xiang-Shan*,a,c, ZENG Zhao-Sena
ZHANG Mei-Meia, SHI Da-Qinga,c, TU Shu-Jianga,c   

  1. (a Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)
    (b Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005)
    (c Key Laboratory on Biotechnology for Medical Plant of Jiangsu Prov-ince, Xuzhou 221116)
  • Received:2006-08-22 Revised:1900-01-01 Published:2007-05-21
  • Contact: WANG Xiang-Shan

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以芳醛、氰乙酸酯和1,5-萘二酚为原料, 以乙醇为溶剂, 在80 ℃以KF/Al2O3为催化剂合成了一系列的2,8-二氨基-4,10-二芳基-4H,10H-二-γ-吡喃并[2,3-a;2',3'-f]萘-3,9-二羧酸酯衍生物, 该反应具有反应条件温和、产率良好、操作方便等优点. 产物的结构通过IR, 1H NMR和元素分析表征, 并进一步通过X射线衍射分析确证4h的结构.

关键词: 2',3'-f]萘, KF-Al2O3, 合成, 二-γ-吡喃并[2,3-a

A series of 2,8-diamino-4,10-diaryl-di-γ-pyrano[2,3-a;2',3'-f]naphthalene-3,9-dicarboxylate de-rivatives have been synthesized by the reaction of aromatic aldehyde, cyanoacetate and 1,5-naphthalenediol in EtOH at 80 ℃ catalyzed by KF/Al2O3. The notable features of this procedure are mild reaction conditions, good yields and operational simplicity. The structures of the products were characterized by IR, 1H NMR spectra and elemental analysis, and 4h was further con-firmed by X-ray diffraction analysis.

Key words: 2',3'-f]naphthalene, KF/Al2O3, synthesis, di-γ-pyrano[2,3-a