有机化学 ›› 1986, Vol. 6 ›› Issue (3): 184-187. 上一篇    下一篇

研究论文

酰氨基硫脲及其相关杂环衍生物的研究II.1-[5-(α-萘)-2H-四唑-2-乙酰[-4-苯基氨基硫脲及其相关环衍生物的合成

张自义;杨虎   

  1. 兰州大学化学系
  • 发布日期:1986-06-25

Studies on the acylthiosemicarbazides and their related heterocyclic derivatives II. Synthesis of 1-[5-(\a\-naphtyl)-2H-tetrazol-2-ylacetyl]-4-phenyl thiosemicarbazide and its related heterocyclic derivatives

ZHANG ZIYI;YANG HU   

  • Published:1986-06-25

本文合成了1-[5-(α-萘)-2-H-四唑2-乙酰]-4-苯基氨基硫脲5,以及由5衍生的环化产物3-[5-(α-萘)-2H-四唑2-甲撑]-4-苯基-1,2,4-三咪啉-5-硫酮6,2-苯胺基-5-[5-(α-萘)-2H-四唑-2-甲撑]-1,3,4-噻二唑7及2-苯胺基-5-[5-(α-萘)-2H-四唑-2-甲撑]-1,3,4-二唑8.它们的结构均通过元素分析,红外光谱,核磁共振及质谱鉴定.其药理实验正在进行中.初步实验表明,5及6对小麦生长有较强的促进作用.

关键词: 红外分光光度法, 质谱法, 核磁共振谱法, 氮杂环化合物, 萘 P, 硫脲, 苯 P, 四唑 P, 酰胺基, 氨基硫脲 P

The title compound (I) was prepared in 81% yield by the reaction of 5-(a-naphthyl)-2H-tetrazol-2-ylacetylhydrazine with PhNCS in EtOH. Cyclization reactions of I in aqueous NaOH, concentrate H2SO4 or Hg(OAc)2-EtOH gave corresponding triazole (II), thiadiazole III (X = S) and oxadiazole III (X = O) resp. I and II showed promoting effects on the growth of plumule of wheat at 1 ppm.

Key words: INFRARED SPECTROPHOTOMETRY, MASS SPECTROGRAPHY, NMR SPECTROMETRY, NITROGEN HETEROCYCLICS, NAPHTHALENE P, THIOUREAS, BENZENE P, TETRAZOLE P, AMIDO, THIOSEMICARBAZIDE P

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