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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (11): 1444-1447. 上一篇    下一篇

研究简报

N-(5-巯基-1,3,4-噻二唑-2-基)-N'-取代苯甲酰基脲与取代的苯氧乙酰基脲的合成与生物活性

陈传兵a,b，张正文a，杜敏a，王胜a，汪焱钢*,a   

  1. (a华中师范大学化学学院 武汉 430079)
    (b广州中医药大学中药学院 广州 510405)
  • 收稿日期:2006-10-09 修回日期:2007-05-08 发布日期:2007-10-20
  • 通讯作者: 汪焱钢

Synthesis and Biological Activity of N-(5-Mercapto-1,3,4-thiadiazol-2- yl)-N'-(un)substituted Benzoylureas and (Un)substituted Phenoxyacetylureas

CHEN Chuan-Binga,b,ZHANG Zheng-Wena,DU Mina
WANG Shenga,WANG Yan-Gang*,a   

  1. (a College of Chemistry, Central China Normal University, Wuhan 430079)
    (b College of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405)
  • Received:2006-10-09 Revised:2007-05-08 Published:2007-10-20
  • Contact: WANG Yan-Gang

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被引次数

1

通过2-氨基-5-巯基-1,3,4-噻二唑与取代苯甲酰基异氰酸酯及取代苯氧乙酰基异氰酸酯反应, 合成了21种新的取代苯甲酰基脲与取代苯氧乙酰基脲, 其结构用红外光谱、核磁共振氢谱和元素分析进行了确证, 初步的生物活性测定试验表明, 部分目标化合物具有良好的植物生长调节活性.

关键词: 取代苯甲酰基脲, 取代苯氧乙酰基脲, 1,3,4-噻二唑, 生物活性, 合成

Twenty-one new (un)substituted benzoylureas and (un)substituted phenoxyacetylureas have been synthesized by the reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with (un)substituted benzoyl isocy-anates and (un)substituted phenoxyacetyl isocyanates, respectively, and their structures were confirmed by IR, 1H NMR spectra and elemental analysis. The preliminary biological activity tests showed that some of the title compounds had good activity as plant growth regulators.

Key words: (un)substituted phenoxyacetylurea, 1,3,4-thiadiazole, biological activity, synthesis, (us)subsitituted benzoylurea