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有机化学
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有机化学 ›› 1989, Vol. 9 ›› Issue (2): 136-140. 上一篇    下一篇

研究论文

有机磷化合物的研究 XXV: 由N,N'-取代亚烷基双酰胺合成α-氨基膦酸

袁承业;袁群;谢贤科   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1989-04-25

Studies on organophosphorus compounds XXV: Synthesis of α -aminophosphonic acids by reaction of N,N-substituted alkylene-biscarboxamides with triphenyl phosphite

YUAN CHENGYE;YUAN QUN;XIE XIANKE   

  • Published:1989-04-25

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报导了亚磷酸三苯酯与对称的N,N'-烷撑二碳酰胺或N-羟在碳酰胺的反应后经水解合成α-氨基膦酸的新方法, 反应机理包括有二碳酰胺对三价磷的亲电进攻.

关键词: 酰胺, 酰胺, 有机磷化合物, 烷烃 P, 碳酸 P, 亚磷酸酯类, 氨基膦酸

A novel method for the synthesis of a-aminophosphonic acids based on the reaction of tri-Ph phosphite on sym. N,N'-alkylenebiscarboxamide or N-hydroxycarboxamide followed by subsequent hydrolysis was reported. Based on the experimental observations, a tentative reaction mechanism involving an electrophilic attack by biscarboxamide on the trivalent phosphorus was suggested.

Key words: AMIDES, AMIDES, ORGANO PHOSPHORUS COMPOUNDS, ALKANE P, CARBONIC ACID P, PHOSPHOROUS ACID ESTER, PHOSPHOAMIDIC ACID

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