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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (2): 261-265. 上一篇    下一篇

研究论文

水介质中4-芳基-3-甲基-1-苯基-4,5,6,7,8,9-六氢化吡唑并[5,4-b]喹啉-5-酮衍生物的三组分一锅合成

史达清*,a,b,c，拾景文b，姚浩b，蒋虹c，王香善b,c   

  1. (a苏州大学化学化工学院 江苏省有机合成重点实验室 苏州 215123)
    (b徐州师范大学化学系 徐州 221116)
    (c江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2007-01-17 修回日期:2007-06-07 发布日期:2008-02-01
  • 通讯作者: 史达清

Three-Component One-Pot Synthesis of 4-Aryl-3-methyl-1-phenyl- 4,5,6,7,8,9-hexahydropyrazolo[5,4-b]quinolin-5-one Derivatives in Aqueous Media

SHI Da-Qing*,a,b,c,SHI Jing-Wenb,YAO Haob,JIANG Hongc,WANG Xiang-Shanb,c   

  1. (a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical En-gineering,
    Suzhou University, Suzhou 215123)
    (b Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)
    (c Key Laboratory of Biotechnology on Medical Plants of Jiangsu Province, Xuzhou 221116)
  • Received:2007-01-17 Revised:2007-06-07 Published:2008-02-01
  • Contact: SHI Da-Qing

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在水介质中有十二烷基磺酸钠(SDS)存在下, 以芳醛、5-氨基-3-甲基-1-苯基吡唑、1,3-环己二酮三组分一锅反应合成了4-芳基-3-甲基-1-苯基-4,5,6,7,8,9-六氢化吡唑并[5,4-b]喹啉-5-酮衍生物, 产物的结构通过IR, 1H NMR确证, 化合物4e的结构经单晶X射线衍射确证.

关键词: 4,5,6,7,8,9-六氢化吡唑并[5,4-b]喹啉-5-酮, 三组分, 水介质, 一锅合成

4-Aryl-3-methyl-1-phenyl-4,5,6,7,8,9-hexahydropyrazolo[5,4-b]quinolin-5-one derivatives were synthesized by a three-component one-pot reaction of aromatic aldehydes, 5-amino-3-methyl-1- phenylpyrazole and 1,3-cyclohexanedione using sodium dodecanesulfonate (SDS) as a catalyst in aqueous media. The structures of products were identified by IR and 1H NMR spectra, and the structure of 4e was confirmed by X-ray diffractional analysis.

Key words: three-component, 4,5,6,7,8,9-hexahydropyrazolo[5,4-b]quinolin-5-one, aqueous media, one-pot synthesis