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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (03): 308-312. 上一篇    下一篇

研究论文

新型氮芥和卤代烷基哌嗪芳香醛的合成

郭灿城*，李可来，童荣标，陈亮，张晓兵   

  1. (湖南大学化学化工学院 长沙 410082)
  • 收稿日期:2004-01-12 修回日期:2004-02-29 发布日期:2005-02-28
  • 通讯作者: 郭灿城

Synthesis of New Aromatic Aldehydes Bearing Nitrogen Mustard Derivatives and Halogenoalkylpiperazinyl

GUO Can-Cheng*,LI Ke-Lai,TONG Rong-Biao,CHEN Liang,ZHANG Xiao-Bing   

  1. (College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082)
  • Received:2004-01-12 Revised:2004-02-29 Published:2005-02-28
  • Contact: GUO Can-Cheng

PDF

2773

被引次数

9

通过对Vilsmeier反应、烷基化反应和氯化反应的改进提出了以简单易得的苯胺和苯基哌嗪为原料制备氮芥和哌嗪芳香醛的方法. 采用该改进的方法合成了8个氮芥和哌嗪芳香醛, 其中7个为新化合物. 它们的结构均经质谱、红外光谱、核磁共振谱和元素分析确证.

关键词: 合成, Vilsmeier反应, 芳香醛, 氮芥, 哌嗪

Modifications of alkylation, chlorination and Vilsmeier reaction were employed for the synthesis of aromatic aldehydes bearing nitrogen mustard derivatives and halogenoalkylpiperazinyl. Thus seven new aromatic aldehydes were synthesized from commercially available aniline and phenylpiperazine by the modified method. All of the desired compounds were characterized by MS, IR, 1H NMR spectra and elemental analysis.

Key words: aromatic aldehyde, nitrogen mustard, Vilsmeier reaction, piperazine, synthesis