有机化学 ›› 1998, Vol. 18 ›› Issue (3): 243-247. 上一篇    下一篇

研究论文

一维多重接力COSY和选择性远程DEPT核磁共振技术在新分子骨架生物碱结构测定和谱峰归属研究中的应用

缪振春;邓京振;赵守训;冯锐;杜泽涵   

  1. 军事医学科学院毒物药物研究所;中国药科大学中草药化学研究室
  • 发布日期:1998-06-25

Structural determination and spectral assignment of an alkaloid with a novel skeleton by selective long-range DEPT and 1D multiple relay COSY NMR techniques

MIU ZHENCHUN;DENG JINGZHEN;ZHAO SHUXUN;FENG RUI;DU ZEHAN   

  • Published:1998-06-25

自防已科千金藤根中分得一个新型分子骨架的四氢异喹啉类生物碱-excentricine(1)。本工作采用一维多重接力COSY和选择性远程DEPT核磁共振新技术成功地确定谱峰归属, 鉴别和连结被季碳和杂原子分割开的自旋体系, 测定了其结构。

关键词: 生物碱, 千金藤, 核磁共振谱法, 四氢化异喹啉生物碱, 异喹啉 P

A novel skeleton alkaloid, excentricine, was isolated from the roots of stephaniaexcentrica. The recent introduced selective long-range DEPT and 1D multiple relay COSY NMR techniques have been successfully used to identify and to connect spin systems separated by quaternary carbons and heterotoms and total assignment of 1H and 13C NMR spectra were achived. Its structure has been elucidated as 1.

Key words: NMR SPECTROMETRY, ISOQUINOLINE P, TETRAHYDROISOQUINOLINE ALKALOID, ALKALOID

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