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有机化学
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有机化学 ›› 2001, Vol. 21 ›› Issue (1): 41-44. 上一篇    下一篇

研究论文

二苯基锗杂环羧酸酯的合成、表征及生物活性研究

张如芬;尹汉东;马春林;邵鑫   

  1. 中国科学院兰州化学物理研究所.兰州(730000);中国科学院兰州化学物理研究 所.兰州(730000)
  • 发布日期:2001-01-25

Synthesis and amtitumor activity of diphenylgermanium heterocyclic carboxylates

Zhang Rufen;Yin Handong;Ma Chunlin;Shao Xin   

  1. Lanzhou Inst Chem Phys, CAS.Lanzhou(730000);Lanzhou Inst Chem Phys, CAS.Lanzhou(730000)
  • Published:2001-01-25

PDF

548

被引次数

14

合成了8种二苯基锗杂环羧酸酯Ph2Ge(O2CR)2(R=2-呋喃基、2-呋喃乙烯基、2-噻吩基、2-吡啶基、3-吡啶基、4-吡啶基、3-吲哚甲基、3-吲哚丙基)，利用元素分析、红外光谱、核磁共振氢谱和质谱表征了这些化合物的结构。体外实验表明，这些化合物对MCF-7、WidDr和EC癌细胞具有较好的抑制活性。

关键词: 二苯基锗, 有机锗化合物, 抗癌药, 羧酸酯, 杂环化合物, 结构表征, 生物活性

Eight new diphenylgermanium heterocyclic carboxylates PH2Ge(O2CR) 2were synthesized by reaction of diphenylgermanium chloride with sodium heterocyclic carboxylates. Their structures were established by elemental analysis,IR,1^H NMR and MS spectorscops.The IR spectra show that in complexes 1～ 8 the carboxyl groups are bidentate ligands. The complexes 1～ 8 all display much higher activity in vitro than those of cis-platin or triphenylgermanium chloride in the experiments against two human tumor cell lines, MCF-7, a mammary tumor, WiDr, a colon carcinoma,and EC, an ascites carcinoma.

Key words: ORGANO GERMANIUM, ANTICARCINOGEN, CARBOXYLIC ACID ESTER, HETEROCYCLIC COMPOUNDS, STRUCTURE CHARACTERISTICS, BIOLOGICAL ACTIVITY

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