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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (11): 1454-1458. 上一篇    下一篇

研究简报

1-吡唑酰基-4-芳基氨基脲类化合物的合成及除草活性

谭成侠*,1，沈德隆1，翁建全1，欧晓明2   

  1. (1浙江工业大学化学工程与材料学院 杭州 310032)
    (2国家南方农药创制中心湖南基地生测部 长沙 410007)
  • 收稿日期:2005-03-27 修回日期:2005-05-17 发布日期:2005-10-30
  • 通讯作者: 谭成侠

Synthesis and Herbicidal Activities of 1-Pyrazol-5'-ylcar-bonyl-4-arylsemicarbazide

TAN Cheng-Xia*,1,SHEN De-Long1,WENG Jian-Quan1,OU Xiao-Ming2   

  1. (1 College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014)
    (2 Bioassay Department, Hunan Branch of National Southern Pesticide Research Centre, Changsha 410007)
  • Received:2005-03-27 Revised:2005-05-17 Published:2005-10-30
  • Contact: TAN Cheng-Xia

PDF

1635

被引次数

32

为了寻求新的含吡唑氨基脲先导化合物, 用4-溴-1-甲基-3-乙基-5-吡唑甲酰肼与取代苯基异氰酸酯反应得到了14个新的含吡唑氨基脲类化合物. 经IR, 1H NMR, MS和元素分析对化合物的结构进行了表征. 初步生物活性实验结果表明, 在225 mg/m2浓度下, 1-(1-甲基-3-乙基-4-溴-5-吡唑甲酰基)-4-(2,4-二甲基苯基)氨基脲(4k)对苘麻(Abutilon theophrasti)、藜(Chenopodium album)及刺苋(Amaranthus spinosus)抑制活性达到100%.

关键词: 吡唑, 氨基脲, 除草活性

In order to find new semicarbazide lead compounds, 1-pyrazol-5'-ylcarbonyl-4-substituted phen-ylsemibazides were synthesized from 4-bromo-3-ethyl-1-methyl-5-hydrazinocarbonylpyrazole and substi-tuted phenyl isocyanate. The structures of all new compounds were confirmed by 1H NMR, IR, MS spectra and elemental analysis. The results of biological tests indicated that, at the concentration of 225 mg/m2, 1-(4-bromo-3-ethyl-1-methyl-pyrazol-5'-ylcarbonyl)-4-(2,4-dimethylphenyl)semicarbazide (4k) showed inhibitory activities (100%) against Abutilon theophrasti, Chenopodium album and Amaranthus spinosus.

Key words: semicarbazide, herbicidal activity, pyrazole