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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (07): 996-1000. 上一篇    下一篇

研究简报

微波辅助一步合成2-取代吲哚

陈静，胡永洲*   

  1. (浙江大学药学院药物化学教研室 杭州 310031)
  • 收稿日期:2005-10-19 修回日期:2006-01-23 发布日期:2006-07-01
  • 通讯作者: 胡永洲

Microwave-Assisted One-Pot Synthesis of 2-Substituted Indoles

CHEN Jing,HU Yong-Zhou*   

  1. (Department of Medicinal Chemistry, School of Pharmaceutical Science, Zhejiang University, Hangzhou 310031)
  • Received:2005-10-19 Revised:2006-01-23 Published:2006-07-01
  • Contact: HU Yong-Zhou

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微波辐射下以取代苯胺1, 2-溴芳基乙酮2为原料, 在无催化剂条件下一步合成了一系列2-取代吲哚3. 该方法具操作简单、反应时间短、产率高等特点.

关键词: 苯胺, 2-溴芳基乙酮, 微波辐射, 吲哚

A series of 2-substituted indoles 3 were synthesized using substituted aniline 1 and 2-bromoace- tophenone 2 as starting materials under microwave irradiation conditions without any catalysts. The reactions were easily worked up with short time and high yields

Key words: indole, 2-bromoacetophenone, microwave irradiation, aniline